Gene Report

Basic Info
Approved Symbol SYNGR1
Approved Name synaptogyrin 1
Location 22q13
Position chr22:39349925-39385588, 1
External Links HGNC: 11498
Entrez Gene: 9145
Ensembl: ENSG00000100321
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Wang, Y.,2009 SNP: rs715505 The frequencies of the alleles or genotypes did not differ significantly between the case group and the control group.No association was found in this study. Negative Comment on Study
Yosifova, A.,2009 SNP: rs715505, rs909685 Significant association of SNP in this gene with BD in our population was observed. Positive Comment on Study
Verma, R.,2005(a) SNP: rs2010904, rs2012906, rs4821888, rs6001566, rs715505, rs739363, rs760741, rs760742, rs909685
Other variant: SYNGR1_exon6_Asn(ins/del), SYNGR1_exon3_Ser97Ser
Our results support SYNGR1 as a probable susceptibility gene for SCZ and BPAD. Also, the observed association of SYNGR1 with both SCZ and BPAD suggests the likely involvement of a common pathway in the etiology of these disorders. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 9)

GO terms by PBA (count: 1)

GO terms by database search (count: 8)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 23)

Literature-origin SNPs (count: 9)

LD-proxies (count: 14)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 4)

Gene relationship with MDD

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Region: chr22:39349925..39385588 View in gBrowse
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