Gene Report

Basic Info
Approved Symbol RYR2
Previous Symbol ARVD2
Symbol Alias ARVC2, VTSIP
Approved Name ryanodine receptor 2 (cardiac)
Previous Name arrhythmogenic right ventricular dysplasia 2
Location 1q43
Position chr1:237042205-237833988, 1
External Links HGNC: 10484
Entrez Gene: 6262
Ensembl: ENSG00000198626
UCSC: uc001hyl.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Prabhu, S.,2012 We found a significant interaction between SNPs located within genes encoding two calcium channel subunits: RYR2 on chr1q43 and CACNA2D4 on chr12p13 (LD-contrast test, ) Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 69)

GO terms by PBA (count: 6)

GO terms by database search (count: 63)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr1:237042205..237833988 View in gBrowse
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