Gene Report

Basic Info
Approved Symbol GSK3B
Approved Name glycogen synthase kinase 3 beta
Location 3q13.3
Position chr3:119821323-120094417, -1
External Links HGNC: 4617
Entrez Gene: 2932
Ensembl: ENSG00000082701
UCSC: uc003edm.3
No. of Studies 8 (Positive: 0; Negative: 8; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 8)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Nievergelt, C. M., 2006 Single SNP TDT analyses showed no evidence for association to BPAD. Negative Comment on Study
Chen G., 2014 SNP: rs334558 In summary, this meta-analysis suggests that the functional polymorphism -50C/T within the GSK3B gene promoter is unlikely to relate with BD risk. Negative Comment on Study
Lee, K. Y., 2006 (b) Haplotype: GSK-3 beta_-1727A/T - GSK-3 beta_-50C/T(A-C, A-T, T-C, T-T)
Other variant: GSK3B_-1727A/T, GSK3B_-50T/C
In conclusion, these results suggest that the GSK-3 beta is not associated with the development of schizophrenia and bipolar disorder in Korean population. Negative Comment on Study
Tang, H., 2013 SNP: rs334558 Here, by using meta-analysis we reported that glycogen synthase kinase 3beta promoter inactive mutant rs334558 may contribute to the development of schizophrenia not bipolar disorder. This might be used to distinguish these two diseases. Negative Comment on Study
Nishiguchi, N., 2006 Other variant: GSK3B_-1727A/T, GSK3B_-50T/C It is unlikely that the GSK3beta-gene is a risk factor for bipolar disorder in our sample, but we cannot exclude the gene completely as other unknown polymorphisms in the gene may increase susceptibility. Negative Comment on Study
Lee, Y. J.,2011 Haplotype: GSK3beta_promoter_1727A/T - GSK3beta_promoter_50C/T()
Other variant: GSK3B_-1727A/T, GSK3B_-50T/C
This study suggests that GSK3beta polymorphisms are not associated with bipolar disorder. Negative Comment on Study
Lin YF, 2013 SNP: rs334558, rs6438552
Haplotype: rs334558 - rs6438552(C-C), rs334558 - rs6438552(C-T), rs334558 - rs6438552(T-C), rs334558 - rs6438552(T-T)
We found no association between each of the two SNPs and the risk of bipolar I disorder. Negative Comment on Study
Saus, E.,2010 SNP: rs1054190, rs11921360, rs11925868, rs11927974, rs13314595, rs334538, rs334555, rs3732360, rs6438552, rs7431209, rs9826659 We could not find evidence for association to either MDD or BP, thus not replicating previous positive results from others with respect to BD diagnosis. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 93)

GO terms by PBA (count: 5)

GO terms by database search (count: 88)

Gene related KEGG pathways (count: 14)

Gene related BioCarta pathways (count: 13)

Gene related interactors from protein-protein interactions data in HPRD (count: 72)

Related other genetic factors
Gene related SNPs (count: 66)

Literature-origin SNPs (count: 12)

LD-proxies (count: 54)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 1)

Overlap with MDD from candidate gene intersection analysis (count: 6)

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Region: chr3:119821323..120094417 View in gBrowse
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