Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CD36
Symbol Alias	SCARB3, GPIV, FAT, GP4, GP3B
Approved Name	CD36 molecule (thrombospondin receptor)
Previous Name	CD36 antigen (collagen type I receptor, thrombospondin receptor)
Location	7q11.2
Position	chr7:80369575-80679277, 1
External Links	HGNC: 1663 Entrez Gene: 948 Ensembl: ENSG00000135218 UCSC: uc003uhg.4
No. of Studies	3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 3)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Abou Jamra, R, 2008 (a)	SNP: rs10008039, rs10009030, rs11724817, rs1298865, rs1300054, rs2249917, rs2304865, rs2306987, rs2306990, rs2584345, rs2637777, rs327070, rs327077, rs327078, rs327079, rs327080, rs327095, rs327102, rs328429, rs328437, rs328438, rs3733413, rs3733414, rs4241833, rs455219, rs459796, rs4862717, rs4862718, rs6818461, rs7663350, rs7683023, rs997696, rs9991886 Haplotype: rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(), rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(AGAGC), rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(TACTG), rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(TGCGG)	In FAT, nine SNPs showed association, eight of them being located in the same haplotype block found to be associated with bipolar affective disorder (BPAD) by Blair et al.	Positive	Comment on Study
Blair, I. P., 2006	SNP: rs1298865, rs2304865, rs2306987 Haplotype: rs2304865 - rs2637777 - rs2306990 - rs1298865 - rs2306987(G-T-G-T-A), rs2304865 - rs2637777 - rs2306990 - rs1298865 - rs2306987(C-G-A-C-T)	These data provide convergent evidence that FAT and its protein partners may be components of a molecular pathway involved in susceptibility to bipolar disorder.	Positive	Comment on Study
Yosifova, A.,2009	SNP: rs1298865, rs2304865, rs2306990, rs2637777	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 74)

GO terms by PBA (count: 5)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045087	innate immune response	biological process	TAS	49
GO:0016020	membrane	cellular component	TAS[2468669]	137
GO:0005886	plasma membrane	cellular component	IDA[22022213]; TAS	360
GO:0007155	cell adhesion	biological process	IEA	42
GO:0005887	integral component of plasma membrane	cellular component	TAS[9568716]	158

GO terms by database search (count: 69)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0071813	lipoprotein particle binding	molecular function	IDA[9568716]	3
GO:0032760	positive regulation of tumor necrosis factor production	biological process	IEA	5
GO:0060907	positive regulation of macrophage cytokine production	biological process	IEA	2
GO:0034383	low-density lipoprotein particle clearance	biological process	IMP[10772654]	2
GO:0015911	plasma membrane long-chain fatty acid transport	biological process	IDA[17416590]	1
GO:0045335	phagocytic vesicle	cellular component	TAS	4
GO:0005794	Golgi apparatus	cellular component	IEA	60
GO:0002576	platelet degranulation	biological process	TAS	5
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEA	14
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	biological process	TAS	8
GO:0032735	positive regulation of interleukin-12 production	biological process	IEA	5
GO:0030168	platelet activation	biological process	TAS	22
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	biological process	TAS	5
GO:0060100	positive regulation of phagocytosis, engulfment	biological process	IEA	1
GO:0071223	cellular response to lipoteichoic acid	biological process	IEA	2
GO:0030301	cholesterol transport	biological process	ISS[12376530]	3
GO:2000334	positive regulation of blood microparticle formation	biological process	IEA	1
GO:0045121	membrane raft	cellular component	IEA	22
GO:0030666	endocytic vesicle membrane	cellular component	TAS	8
GO:0005041	low-density lipoprotein receptor activity	molecular function	IMP[10772654]; TAS[9568716]	1
GO:0055096	low-density lipoprotein particle mediated signaling	biological process	IEA	2
GO:0019934	cGMP-mediated signaling	biological process	IDA[17416590]	2
GO:0050830	defense response to Gram-positive bacterium	biological process	IEA	7
GO:0031092	platelet alpha granule membrane	cellular component	TAS	1
GO:0006910	phagocytosis, recognition	biological process	IEA	1
GO:0009897	external side of plasma membrane	cellular component	IEA	21
GO:0042992	negative regulation of transcription factor import into nucleus	biological process	IEA	2
GO:0005615	extracellular space	cellular component	IDA[16502470]	85
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	biological process	IEA	12
GO:0070053	thrombospondin receptor activity	molecular function	ISS	1
GO:0044255	cellular lipid metabolic process	biological process	TAS	13
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS	8
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway	biological process	TAS	8
GO:0071447	cellular response to hydroperoxide	biological process	IEA	1
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway	biological process	TAS	8
GO:0043410	positive regulation of MAPK cascade	biological process	IEA	13
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IEA	62
GO:0019915	lipid storage	biological process	IMP[10772654]	4
GO:0007263	nitric oxide mediated signal transduction	biological process	IDA[17416590]	5
GO:0035634	response to stilbenoid	biological process	IEA	2
GO:0008035	high-density lipoprotein particle binding	molecular function	IEA	2
GO:0009986	cell surface	cellular component	IDA[10772654]; ISS	40
GO:0030194	positive regulation of blood coagulation	biological process	IEA	1
GO:0008289	lipid binding	molecular function	IDA[10772654]	8
GO:0071222	cellular response to lipopolysaccharide	biological process	IEA	12
GO:0044130	negative regulation of growth of symbiont in host	biological process	IEA	5
GO:0010886	positive regulation of cholesterol storage	biological process	IEA	2
GO:0032755	positive regulation of interleukin-6 production	biological process	IEA	8
GO:2000379	positive regulation of reactive oxygen species metabolic process	biological process	IEA	4
GO:0006898	receptor-mediated endocytosis	biological process	TAS	12
GO:0071221	cellular response to bacterial lipopeptide	biological process	IEA	1
GO:0001954	positive regulation of cell-matrix adhesion	biological process	IDA[17416590]	4
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	biological process	TAS	7
GO:0044539	long-chain fatty acid import	biological process	IDA[22022213]	2
GO:2000121	regulation of removal of superoxide radicals	biological process	IEA	1
GO:0010744	positive regulation of macrophage derived foam cell differentiation	biological process	IMP[10772654]	4
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I	biological process	TAS	5
GO:0007166	cell surface receptor signaling pathway	biological process	IEA	23
GO:0042953	lipoprotein transport	biological process	IMP[10772654]; TAS[9568716]	2
GO:0070892	lipoteichoic acid receptor activity	molecular function	IEA	1
GO:0007596	blood coagulation	biological process	TAS	44
GO:0030169	low-density lipoprotein particle binding	molecular function	IDA[10772654]	2
GO:0034381	plasma lipoprotein particle clearance	biological process	ISS[12376530]	1
GO:0043277	apoptotic cell clearance	biological process	IEA	3
GO:0002224	toll-like receptor signaling pathway	biological process	TAS	10
GO:0034134	toll-like receptor 2 signaling pathway	biological process	TAS	8
GO:0050431	transforming growth factor beta binding	molecular function	ISS	1
GO:0006629	lipid metabolic process	biological process	NAS[7518447]	10

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 3)

ID	Name	No. of Genes in BDgene
hsa04512	ECM-receptor interaction	9
hsa04920	Adipocytokine signaling pathway	8
hsa03320	PPAR signaling pathway	4

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04640	Hematopoietic cell lineage	5

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
tsp1Pathway	TSP-1 Induced Apoptosis in Microvascular Endothelial Cell	2
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CD36	COL1A1	NO	in vitro	2468670
CD36	ITGA6	NO	in vivo	11238109
CD36	THBS1	NO	in vivo	10772961 , 10487979
CD36	ITGB3	NO	in vivo	11238109
CD36	LYN	NO	in vivo	1715582
CD36	SRC	NO	in vivo	7521304
CD36	MATK	NO	in vivo	9171348
CD36	CD9	NO	in vivo	11238109
CD36	ITGB1	NO	in vivo	11238109
CD36	YES1	NO	in vivo	7521304
CD36	ITGA2B	NO	in vivo	11238109
CD36	COL1A2	NO	in vitro	10772928

Related other genetic factors

Gene related SNPs (count: 33)

Literature-origin SNPs (count: 33)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs327070	chr4:186703040 - 186703040(1)	intron_variant	1(0/1/0)
rs2306990	chr4:186597822 - 186597822(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	2(1/1/0)
rs327102	chr4:186719682 - 186719682(1)	intron_variant	1(0/1/0)
rs455219	chr4:186700910 - 186700910(1)	intron_variant	1(0/1/0)
rs459796	chr4:186680205 - 186680205(1)	intron_variant	1(0/1/0)
rs4862718	chr4:186579734 - 186579734(1)		1(1/0/0)
rs327080	chr4:186672805 - 186672805(1)	intron_variant	1(0/1/0)
rs1298865	chr4:186595726 - 186595726(1)	5_prime_UTR_variant; downstream_gene_variant; NMD_transcript_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; synonymous_variant	3(2/1/0)
rs7683023	chr4:186580234 - 186580234(1)		1(1/0/0)
rs7663350	chr4:186640644 - 186640644(1)	intron_variant	1(0/1/0)
rs11724817	chr4:186668644 - 186668644(1)	intron_variant	1(0/1/0)
rs328429	chr4:186653747 - 186653747(1)	intron_variant	1(0/1/0)
rs997696	chr4:186698416 - 186698416(1)	intron_variant	1(0/1/0)
rs3733413	chr4:186708384 - 186708384(1)	missense_variant	1(0/1/0)
rs3733414	chr4:186708616 - 186708616(1)	missense_variant	1(0/1/0)
rs328437	chr4:186627509 - 186627509(1)	intron_variant	1(1/0/0)
rs2584345	chr4:186606664 - 186606664(1)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(0/1/0)
rs2306987	chr4:186595501 - 186595501(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	2(2/0/0)
rs10009030	chr4:186599883 - 186599883(1)	downstream_gene_variant; intron_variant; upstream_gene_variant	1(1/0/0)
rs328438	chr4:186627675 - 186627675(1)	intron_variant	1(0/1/0)
rs327077	chr4:186669313 - 186669313(1)	intron_variant	1(0/1/0)
rs9991886	chr4:186614065 - 186614065(1)	intron_variant; upstream_gene_variant	1(0/1/0)
rs2249917	chr4:186613221 - 186613221(1)	synonymous_variant; upstream_gene_variant	1(0/1/0)
rs10008039	chr4:186612191 - 186612191(1)	intron_variant; upstream_gene_variant	1(0/1/0)
rs327078	chr4:186673904 - 186673904(1)	intron_variant	1(0/1/0)
rs4862717	chr4:186576520 - 186576520(1)		1(0/1/0)
rs2304865	chr4:186604209 - 186604209(1)	intron_variant; upstream_gene_variant	3(2/1/0)
rs327095	chr4:186717482 - 186717482(1)	intron_variant	1(0/1/0)
rs327079	chr4:186673006 - 186673006(1)	intron_variant	1(0/1/0)
rs1300054	chr4:186643309 - 186643309(1)	intron_variant	1(0/1/0)
rs2637777	chr4:186603866 - 186603866(1)	missense_variant; upstream_gene_variant	2(1/1/0)
rs4241833	chr4:186576950 - 186576950(1)		1(0/1/0)
rs6818461	chr4:186700127 - 186700127(1)	intron_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q21	chr7:77900000-98400000	4 (0/2/2)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
Chr 7	chr7:0-159345973	3 (0/3/0)
7p15-q21	chr7:20900000-98400000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:80369575..80679277 View in gBrowse