Gene Report

Basic Info
Approved Symbol CD36
Symbol Alias SCARB3, GPIV, FAT, GP4, GP3B
Approved Name CD36 molecule (thrombospondin receptor)
Previous Name CD36 antigen (collagen type I receptor, thrombospondin receptor)
Location 7q11.2
Position chr7:80369575-80679277, 1
External Links HGNC: 1663
Entrez Gene: 948
Ensembl: ENSG00000135218
UCSC: uc003uhg.4
No. of Studies 3 (Positive: 2; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Abou Jamra, R, 2008 (a) SNP: rs10008039, rs10009030, rs11724817, rs1298865, rs1300054, rs2249917, rs2304865, rs2306987, rs2306990, rs2584345, rs2637777, rs327070, rs327077, rs327078, rs327079, rs327080, rs327095, rs327102, rs328429, rs328437, rs328438, rs3733413, rs3733414, rs4241833, rs455219, rs459796, rs4862717, rs4862718, rs6818461, rs7663350, rs7683023, rs997696, rs9991886
Haplotype: rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(), rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(AGAGC), rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(TACTG), rs2306987 - rs1298865 - rs10009030 - rs2637777 - rs2304865(TGCGG)
In FAT, nine SNPs showed association, eight of them being located in the same haplotype block found to be associated with bipolar affective disorder (BPAD) by Blair et al. Positive Comment on Study
Blair, I. P., 2006 SNP: rs1298865, rs2304865, rs2306987
Haplotype: rs2304865 - rs2637777 - rs2306990 - rs1298865 - rs2306987(G-T-G-T-A), rs2304865 - rs2637777 - rs2306990 - rs1298865 - rs2306987(C-G-A-C-T)
These data provide convergent evidence that FAT and its protein partners may be components of a molecular pathway involved in susceptibility to bipolar disorder. Positive Comment on Study
Yosifova, A.,2009 SNP: rs1298865, rs2304865, rs2306990, rs2637777 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 74)

GO terms by PBA (count: 5)

GO terms by database search (count: 69)

Gene related KEGG pathways (count: 4)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

Gene related interactors from protein-protein interactions data in HPRD (count: 12)

Related other genetic factors
Gene related SNPs (count: 33)

Literature-origin SNPs (count: 33)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:80369575..80679277 View in gBrowse
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