Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PIK3CG
Approved Name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Previous Name	phosphoinositide-3-kinase, catalytic, gamma polypeptide
Location	7q22
Position	chr7:106865278-106907145, 1
External Links	HGNC: 8978 Entrez Gene: 5294 Ensembl: ENSG00000105851 UCSC: uc003vdv.5
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs17847825	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 51)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004672	protein kinase activity	molecular function	TAS[19376709]	13
GO:0045087	innate immune response	biological process	TAS[17290298]	49
GO:0004674	protein serine/threonine kinase activity	molecular function	IEA	27
GO:0006954	inflammatory response	biological process	TAS[17290298]	23
GO:0016020	membrane	cellular component	IDA[12507995]	137
GO:0005886	plasma membrane	cellular component	IBA	360

GO terms by database search (count: 45)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042629	mast cell granule	cellular component	TAS[17290298]	2
GO:0070527	platelet aggregation	biological process	TAS[21035500]	4
GO:0043303	mast cell degranulation	biological process	TAS[17290298]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0010897	negative regulation of triglyceride catabolic process	biological process	IEA	1
GO:0032252	secretory granule localization	biological process	IEA	2
GO:0030168	platelet activation	biological process	TAS	22
GO:0010818	T cell chemotaxis	biological process	TAS[18278175]	1
GO:0043406	positive regulation of MAP kinase activity	biological process	IDA[12507995]	6
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	biological process	IEA	5
GO:0002407	dendritic cell chemotaxis	biological process	TAS[18278175]	1
GO:0006897	endocytosis	biological process	IEA	15
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13
GO:0002250	adaptive immune response	biological process	TAS[17290298]	5
GO:0042098	T cell proliferation	biological process	TAS[19075988]	5
GO:0014065	phosphatidylinositol 3-kinase signaling	biological process	IDA[12507995]; TAS[17290298]	5
GO:0005737	cytoplasm	cellular component	IDA[12507995]	322
GO:0001525	angiogenesis	biological process	IEA	20
GO:0007596	blood coagulation	biological process	TAS	44
GO:0006644	phospholipid metabolic process	biological process	TAS	18
GO:0055118	negative regulation of cardiac muscle contraction	biological process	TAS[19147653]	1
GO:0002679	respiratory burst involved in defense response	biological process	TAS[19075988]	1
GO:0046875	ephrin receptor binding	molecular function	IPI[11416136]	5
GO:0002675	positive regulation of acute inflammatory response	biological process	IEA	2
GO:0072672	neutrophil extravasation	biological process	TAS[18278175]	1
GO:0051897	positive regulation of protein kinase B signaling	biological process	IDA[12507995]	11
GO:0033628	regulation of cell adhesion mediated by integrin	biological process	TAS[18278175]	1
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	molecular function	IBA	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	21
GO:0005944	phosphatidylinositol 3-kinase complex, class IB	cellular component	IDA[12507995]	1
GO:2000270	negative regulation of fibroblast apoptotic process	biological process	IEA	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	molecular function	IBA	3
GO:0097284	hepatocyte apoptotic process	biological process	IEA	1
GO:0006468	protein phosphorylation	biological process	IEA	42
GO:0042110	T cell activation	biological process	TAS[17290298]	9
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0035004	phosphatidylinositol 3-kinase activity	molecular function	TAS[17290298]	2
GO:0030593	neutrophil chemotaxis	biological process	TAS[17290298]	8
GO:0001816	cytokine production	biological process	TAS[19075988]	4
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[12507995]	64
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular function	IBA	2
GO:0035747	natural killer cell chemotaxis	biological process	TAS[18278175]	1
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	10
GO:0005515	protein binding	molecular function	IPI[12507995]	563

Gene related KEGG pathways (count: 28)

KEGG pathways by PBA (count: 7)

ID	Name	No. of Genes in BDgene
hsa05214	Glioma	9
hsa04070	Phosphatidylinositol signaling system	16
hsa05221	Acute myeloid leukemia	7
hsa05222	Small cell lung cancer	8
hsa04210	Apoptosis	12
hsa04510	Focal adhesion	22
hsa00562	Inositol phosphate metabolism	11

KEGG pathways by database search (count: 21)

ID	Name	No. of Genes in BDgene
hsa05211	Renal cell carcinoma	6
hsa05210	Colorectal cancer	14
hsa05213	Endometrial cancer	10
hsa05212	Pancreatic cancer	10
hsa05215	Prostate cancer	18
hsa04012	ErbB signaling pathway	13
hsa05218	Melanoma	7
hsa05220	Chronic myeloid leukemia	6
hsa05223	Non-small cell lung cancer	8
hsa04150	mTOR signaling pathway	5
hsa04370	VEGF signaling pathway	11
hsa04650	Natural killer cell mediated cytotoxicity	13
hsa04660	T cell receptor signaling pathway	13
hsa04630	Jak-STAT signaling pathway	14
hsa04620	Toll-like receptor signaling pathway	10
hsa04670	Leukocyte transendothelial migration	13
hsa04664	Fc epsilon RI signaling pathway	13
hsa04662	B cell receptor signaling pathway	8
hsa04930	Type II diabetes mellitus	11
hsa04910	Insulin signaling pathway	10
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 33)

BioCarta pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
badPathway	Regulation of BAD phosphorylation	9

BioCarta pathways by database search (count: 32)

ID	Name	No. of Genes in BDgene
hcmvPathway	Human Cytomegalovirus and Map Kinase Pathways	5
insulinPathway	Insulin Signaling Pathway	4
Par1Pathway	Thrombin signaling and protease-activated receptors	4
rasPathway	Ras Signaling Pathway	5
arfPathway	Tumor Suppressor Arf Inhibits Ribosomal Biogenesis	4
igf1Pathway	IGF-1 Signaling Pathway	4
gcrPathway	Corticosteroids and cardioprotection	9
aktPathway	AKT Signaling Pathway	6
pdgfPathway	PDGF Signaling Pathway	5
longevityPathway	The IGF-1 Receptor and Longevity	6
tffPathway	Trefoil Factors Initiate Mucosal Healing	4
il7Pathway	IL-7 Signal Transduction	6
vegfPathway	VEGF, Hypoxia, and Angiogenesis	4
rac1Pathway	Rac 1 cell motility signaling pathway	6
gleevecpathway	Inhibition of Cellular Proliferation by Gleevec	4
erk5Pathway	Role of Erk5 in Neuronal Survival	5
hdacPathway	Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)	10
her2Pathway	Role of ERBB2 in Signal Transduction and Oncology	7
fcer1Pathway	Fc Epsilon Receptor I Signaling in Mast Cells	5
il2rbPathway	IL-2 Receptor Beta Chain in T cell Activation	6
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12
metPathway	Signaling of Hepatocyte Growth Factor Receptor	2
ngfPathway	Nerve growth factor pathway (NGF)	5
tcrPathway	T Cell Receptor Signaling Pathway	7
nfatPathway	NFAT and Hypertrophy of the heart (Transcription in the broken heart)	11
ecmPathway	Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia	4
ctcfPathway	CTCF: First Multivalent Nuclear Factor	3
achPathway	Role of nicotinic acetylcholine receptors in the regulation of apoptosis	6
TPOPathway	TPO Signaling Pathway	4
plcPathway	Phospholipase C Signaling Pathway	4
ghPathway	Growth Hormone Signaling Pathway	4
edg1Pathway	Phospholipids as signalling intermediaries	4

Gene related interactors from protein-protein interactions data in HPRD (count: 17)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PIK3CG	LYN	NO	in vivo	10318860
PIK3CG	IL6ST	NO	in vivo	10579793
PIK3CG	SMPD2	NO	in vivo	11238738
PIK3CG	GSN	NO	in vitro;in vivo	11577104
PIK3CG	TPM2	NO	in vitro;in vivo	16094730
PIK3CG	NOTCH1	NO	in vivo	14583609
PIK3CG	KIT	NO	in vitro;in vivo	7520444
PIK3CG	GAB1	NO	yeast 2-hybrid	10871282
PIK3CG	EPHA8	NO	in vitro;in vivo	11416136
PIK3CG	CD28	NO	in vivo	9915850
PIK3CG	GRB2	NO	in vivo	10386953
PIK3CG	KRAS	NO	in vivo	10542052
PIK3CG	SEC14L2	NO	in vitro	12757856
PIK3CG	PIK3R5	NO	in vivo	12507995 , 10488142
PIK3CG	PTPN11	NO	in vivo	10386953
PIK3CG	ADRBK1	NO	in vivo	12163475
PIK3CG	HRAS	NO	in vitro	11136978

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17847825	chr7:106868886 - 106868886(1)	intron_variant; missense_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q22.3	chr7:104900000-107800000	1 (1/0/0)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
17893707	598	Negative

Gene relationship with MDD

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Region: chr7:106865278..106907145 View in gBrowse