Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	PIK3CG
Approved Name	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Previous Name	phosphoinositide-3-kinase, catalytic, gamma polypeptide
Location	7q22
Position	chr7:106865278-106907145, 1
External Links	HGNC: 8978 Entrez Gene: 5294 Ensembl: ENSG00000105851 UCSC: uc003vdv.5
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs17847825	Putative damaging exonic variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 51)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004672	protein kinase activity	molecular function	TAS[19376709]	13
GO:0045087	innate immune response	biological process	TAS[17290298]	49
GO:0004674	protein serine/threonine kinase activity	molecular function	IEA	27
GO:0006954	inflammatory response	biological process	TAS[17290298]	23
GO:0016020	membrane	cellular component	IDA[12507995]	137
GO:0005886	plasma membrane	cellular component	IBA	360

GO terms by database search (count: 45)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042629	mast cell granule	cellular component	TAS[17290298]	2
GO:0070527	platelet aggregation	biological process	TAS[21035500]	4
GO:0043303	mast cell degranulation	biological process	TAS[17290298]	1
GO:0005524	ATP binding	molecular function	IEA	118
GO:0010897	negative regulation of triglyceride catabolic process	biological process	IEA	1
GO:0032252	secretory granule localization	biological process	IEA	2
GO:0030168	platelet activation	biological process	TAS	22
GO:0010818	T cell chemotaxis	biological process	TAS[18278175]	1
GO:0043406	positive regulation of MAP kinase activity	biological process	IDA[12507995]	6
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process	biological process	IEA	5
GO:0002407	dendritic cell chemotaxis	biological process	TAS[18278175]	1
GO:0006897	endocytosis	biological process	IEA	15
GO:0006661	phosphatidylinositol biosynthetic process	biological process	TAS	13
GO:0002250	adaptive immune response	biological process	TAS[17290298]	5
GO:0042098	T cell proliferation	biological process	TAS[19075988]	5
GO:0014065	phosphatidylinositol 3-kinase signaling	biological process	IDA[12507995]; TAS[17290298]	5
GO:0005737	cytoplasm	cellular component	IDA[12507995]	322
GO:0001525	angiogenesis	biological process	IEA	20
GO:0007596	blood coagulation	biological process	TAS	44
GO:0006644	phospholipid metabolic process	biological process	TAS	18
GO:0055118	negative regulation of cardiac muscle contraction	biological process	TAS[19147653]	1
GO:0002679	respiratory burst involved in defense response	biological process	TAS[19075988]	1
GO:0046875	ephrin receptor binding	molecular function	IPI[11416136]	5
GO:0002675	positive regulation of acute inflammatory response	biological process	IEA	2
GO:0072672	neutrophil extravasation	biological process	TAS[18278175]	1
GO:0051897	positive regulation of protein kinase B signaling	biological process	IDA[12507995]	11
GO:0033628	regulation of cell adhesion mediated by integrin	biological process	TAS[18278175]	1
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	molecular function	IBA	1
GO:0005829	cytosol	cellular component	TAS	223
GO:0007204	positive regulation of cytosolic calcium ion concentration	biological process	IEA	21
GO:0005944	phosphatidylinositol 3-kinase complex, class IB	cellular component	IDA[12507995]	1
GO:2000270	negative regulation of fibroblast apoptotic process	biological process	IEA	1
GO:0016303	1-phosphatidylinositol-3-kinase activity	molecular function	IBA	3
GO:0097284	hepatocyte apoptotic process	biological process	IEA	1
GO:0006468	protein phosphorylation	biological process	IEA	42
GO:0042110	T cell activation	biological process	TAS[17290298]	9
GO:0044281	small molecule metabolic process	biological process	TAS	117
GO:0035004	phosphatidylinositol 3-kinase activity	molecular function	TAS[17290298]	2
GO:0030593	neutrophil chemotaxis	biological process	TAS[17290298]	8
GO:0001816	cytokine production	biological process	TAS[19075988]	4
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IDA[12507995]	64
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity	molecular function	IBA	2
GO:0035747	natural killer cell chemotaxis	biological process	TAS[18278175]	1
GO:0046854	phosphatidylinositol phosphorylation	biological process	IEA	10
GO:0005515	protein binding	molecular function	IPI[12507995]	563

Gene related KEGG pathways (count: 28)

KEGG pathways by PBA (count: 7)

ID	Name	No. of Genes in BDgene
hsa05214	Glioma	9
hsa04070	Phosphatidylinositol signaling system	16
hsa05221	Acute myeloid leukemia	7
hsa05222	Small cell lung cancer	8
hsa04210	Apoptosis	12
hsa04510	Focal adhesion	22
hsa00562	Inositol phosphate metabolism	11

KEGG pathways by database search (count: 21)

ID	Name	No. of Genes in BDgene
hsa05211	Renal cell carcinoma	6
hsa05210	Colorectal cancer	14
hsa05213	Endometrial cancer	10
hsa05212	Pancreatic cancer	10
hsa05215	Prostate cancer	18
hsa04012	ErbB signaling pathway	13
hsa05218	Melanoma	7
hsa05220	Chronic myeloid leukemia	6
hsa05223	Non-small cell lung cancer	8
hsa04150	mTOR signaling pathway	5
hsa04370	VEGF signaling pathway	11
hsa04650	Natural killer cell mediated cytotoxicity	13
hsa04660	T cell receptor signaling pathway	13
hsa04630	Jak-STAT signaling pathway	14
hsa04620	Toll-like receptor signaling pathway	10
hsa04670	Leukocyte transendothelial migration	13
hsa04664	Fc epsilon RI signaling pathway	13
hsa04662	B cell receptor signaling pathway	8
hsa04930	Type II diabetes mellitus	11
hsa04910	Insulin signaling pathway	10
hsa04810	Regulation of actin cytoskeleton	24

Gene related BioCarta pathways (count: 33)

BioCarta pathways by PBA (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
badPathway	Regulation of BAD phosphorylation	9

BioCarta pathways by database search (count: 32)

ID	Name	No. of Genes in BDgene
vegfPathway	VEGF, Hypoxia, and Angiogenesis	4
ecmPathway	Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia	4
hdacPathway	Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)	10
plcPathway	Phospholipase C Signaling Pathway	4
nfatPathway	NFAT and Hypertrophy of the heart (Transcription in the broken heart)	11
her2Pathway	Role of ERBB2 in Signal Transduction and Oncology	7
TPOPathway	TPO Signaling Pathway	4
pdgfPathway	PDGF Signaling Pathway	5
ghPathway	Growth Hormone Signaling Pathway	4
achPathway	Role of nicotinic acetylcholine receptors in the regulation of apoptosis	6
edg1Pathway	Phospholipids as signalling intermediaries	4
rasPathway	Ras Signaling Pathway	5
aktPathway	AKT Signaling Pathway	6
gcrPathway	Corticosteroids and cardioprotection	9
gleevecpathway	Inhibition of Cellular Proliferation by Gleevec	4
longevityPathway	The IGF-1 Receptor and Longevity	6
il2rbPathway	IL-2 Receptor Beta Chain in T cell Activation	6
ngfPathway	Nerve growth factor pathway (NGF)	5
erk5Pathway	Role of Erk5 in Neuronal Survival	5
arfPathway	Tumor Suppressor Arf Inhibits Ribosomal Biogenesis	4
tffPathway	Trefoil Factors Initiate Mucosal Healing	4
il7Pathway	IL-7 Signal Transduction	6
hcmvPathway	Human Cytomegalovirus and Map Kinase Pathways	5
Par1Pathway	Thrombin signaling and protease-activated receptors	4
tcrPathway	T Cell Receptor Signaling Pathway	7
rac1Pathway	Rac 1 cell motility signaling pathway	6
insulinPathway	Insulin Signaling Pathway	4
ctcfPathway	CTCF: First Multivalent Nuclear Factor	3
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12
metPathway	Signaling of Hepatocyte Growth Factor Receptor	2
igf1Pathway	IGF-1 Signaling Pathway	4
fcer1Pathway	Fc Epsilon Receptor I Signaling in Mast Cells	5

Gene related interactors from protein-protein interactions data in HPRD (count: 17)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PIK3CG	KRAS	NO	in vivo	10542052
PIK3CG	TPM2	NO	in vitro;in vivo	16094730
PIK3CG	SEC14L2	NO	in vitro	12757856
PIK3CG	HRAS	NO	in vitro	11136978
PIK3CG	KIT	NO	in vitro;in vivo	7520444
PIK3CG	GAB1	NO	yeast 2-hybrid	10871282
PIK3CG	ADRBK1	NO	in vivo	12163475
PIK3CG	CD28	NO	in vivo	9915850
PIK3CG	SMPD2	NO	in vivo	11238738
PIK3CG	EPHA8	NO	in vitro;in vivo	11416136
PIK3CG	LYN	NO	in vivo	10318860
PIK3CG	NOTCH1	NO	in vivo	14583609
PIK3CG	IL6ST	NO	in vivo	10579793
PIK3CG	PIK3R5	NO	in vivo	12507995 , 10488142
PIK3CG	GSN	NO	in vitro;in vivo	11577104
PIK3CG	PTPN11	NO	in vivo	10386953
PIK3CG	GRB2	NO	in vivo	10386953

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs17847825	chr7:106868886 - 106868886(1)	intron_variant; missense_variant	1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q22.3	chr7:104900000-107800000	1 (1/0/0)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Reference	ID in SZGene	Result Category
17893707	598	Negative

Gene relationship with MDD

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Region: chr7:106865278..106907145 View in gBrowse