Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	NRIP1
Symbol Alias	RIP140
Approved Name	nuclear receptor interacting protein 1
Name Alias	receptor interacting protein 140, "nuclear factor RIP140"
Location	21q11.2
Position	chr21:14961235-15065936, -1
External Links	HGNC: 8001 Entrez Gene: 8204 Ensembl: ENSG00000180530 UCSC: uc002yjx.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Djurovic, S.,2010	SNP: rs1292735, rs423804	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 2)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005634	nucleus	cellular component	IDA	283
GO:0003714	transcription corepressor activity	molecular function	IDA[10364267]	21

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0019915	lipid storage	biological process	IEA	4
GO:0032922	circadian regulation of gene expression	biological process	IMP[21628546]	22
GO:0005730	nucleolus	cellular component	IDA	28
GO:0046965	retinoid X receptor binding	molecular function	IEA	1
GO:0016607	nuclear speck	cellular component	IEA	16
GO:0005515	protein binding	molecular function	IPI[1266503]	563
GO:0035259	glucocorticoid receptor binding	molecular function	IPI[10364267]	3
GO:0003713	transcription coactivator activity	molecular function	IDA[10364267]; NAS[15572661]	22
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0045893	positive regulation of transcription, DNA-templated	biological process	NAS[15572661]	58
GO:0030521	androgen receptor signaling pathway	biological process	NAS[15572661]	5
GO:0001543	ovarian follicle rupture	biological process	IEA	2
GO:0050681	androgen receptor binding	molecular function	NAS[15572661]	4
GO:0000118	histone deacetylase complex	cellular component	IEA	2
GO:0042826	histone deacetylase binding	molecular function	IEA	13
GO:0035257	nuclear hormone receptor binding	molecular function	IPI[11518808]	5
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	biological process	IDA[10364267]	62
GO:0001046	core promoter sequence-specific DNA binding	molecular function	IDA[21628546]	10
GO:0030054	cell junction	cellular component	IDA	88
GO:0030331	estrogen receptor binding	molecular function	IPI[7641693]	3
GO:0007623	circadian rhythm	biological process	IEP[21628546]	40
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	biological process	IDA[10364267]	91

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
pparaPathway	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)	12

Gene related interactors from protein-protein interactions data in HPRD (count: 36)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
NRIP1	VDR	NO	yeast 2-hybrid	15604093
NRIP1	HNF4A	YES	yeast 2-hybrid	15604093
NRIP1	RXRB	NO	in vitro;yeast 2-hybrid	12549917 , 12403842 , 9013766 , 11278635
NRIP1	PPARG	NO	in vitro;yeast 2-hybrid	9626662
NRIP1	RARA	NO	in vitro;yeast 2-hybrid	10531331 , 16713569 , 12549917
NRIP1	RXRA	NO	in vitro	8887632
NRIP1	CEP70	NO	yeast 2-hybrid	16189514
NRIP1	ESR2	NO	yeast 2-hybrid	15604093
NRIP1	CTBP2	YES	yeast 2-hybrid	16189514 , 15060175
NRIP1	HDAC5	NO	in vitro;in vivo	15060175
NRIP1	RORB	YES	yeast 2-hybrid	15604093
NRIP1	HDAC2	NO	in vitro	15060175
NRIP1	ACTN2	NO	yeast 2-hybrid	15604093
NRIP1	TEX11	NO	yeast 2-hybrid	16189514
NRIP1	NR3C1	YES	in vitro;in vivo	12773562 , 10364267
NRIP1	NR5A1	NO	in vitro;in vivo;yeast 2-hybrid	12782406 , 11459805
NRIP1	CTBP1	NO	in vitro;in vivo;yeast 2-hybrid	11509661 , 15060175
NRIP1	JUN	NO	in vitro;in vivo	12554755
NRIP1	NR1H3	NO	in vitro;yeast 2-hybrid	10022764 , 15604093
NRIP1	PPARA	NO	in vitro;yeast 2-hybrid	10022764 , 9626662
NRIP1	CCDC85B	NO	yeast 2-hybrid	16189514
NRIP1	NR5A2	NO	yeast 2-hybrid	15604093
NRIP1	NR0B1	NO	in vitro;in vivo;yeast 2-hybrid	11459805
NRIP1	TNFRSF14	NO	in vitro;in vivo;yeast 2-hybrid	9774688
NRIP1	MAP3K7	NO	in vitro	9556573
NRIP1	NR2C1	NO	in vitro;in vivo;yeast 2-hybrid	9774688
NRIP1	HDAC1	NO	in vitro;in vivo	11006275 , 11285237 , 15060175
NRIP1	THRB	NO	yeast 2-hybrid	15604093
NRIP1	LDOC1	NO	yeast 2-hybrid	16189514
NRIP1	TRAF2	NO	yeast 2-hybrid	16189514
NRIP1	PRMT1	NO	in vitro;in vivo	17053781
NRIP1	NR1H2	NO	yeast 2-hybrid	15604093
NRIP1	KAT2B	NO	in vitro;in vivo	11509661 , 14581481
NRIP1	AR	NO	in vivo	9368054
NRIP1	HDAC3	NO	in vitro;in vivo	11006275 , 17053781
NRIP1	ESRRG	YES	yeast 2-hybrid	15604093

Related other genetic factors

Gene related SNPs (count: 2)

Literature-origin SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1292735	chr21:14730332 - 14730332(1)		1(0/1/0)
rs423804	chr21:14725134 - 14725134(1)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 21	chr21:0-46709983	1 (0/1/0)
21q11.2-q21.3	chr21:13000000-30200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr21:14961235..15065936 View in gBrowse