Gene Report

Basic Info
Approved Symbol TSPAN8
Previous Symbol TM4SF3
Symbol Alias CO-029
Approved Name tetraspanin 8
Previous Name transmembrane 4 superfamily member 3
Location 12q14.1-q21.1
Position chr12:71125085-71441898, -1
External Links HGNC: 11855
Entrez Gene: 7103
Ensembl: ENSG00000127324
UCSC: uc001swj.1
No. of Studies 2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Sklar, P., 2008 SNP: rs1705236 Our strongest single SNP results are found in myosin5B (TSPAN8; P-value = 6.11E-07). Haplotype analysis further supported single SNP results highlighting TSPAN8 (P-value = 7.57E-07) Trend Comment on Study
Scholz, C. J.,2010 SNP: rs11178655, rs1397552, rs1705233, rs1705236, rs17109370, rs17226863, rs17849952, rs1796330, rs1798086, rs2270586, rs3763978, rs3794217, rs4500567, rs4760908
Haplotype: rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-A-G-C-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-G-C-C-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-G-G-C-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-G-G-G-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(T-G-G-C-A)
This suggests that TSPAN8 contributes to both diseases. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 3)

GO terms by PBA (count: 1)

GO terms by database search (count: 2)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 77)

Literature-origin SNPs (count: 14)

LD-proxies (count: 63)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

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Region: chr12:71125085..71441898 View in gBrowse
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