BDgene

Gene Report

Basic information Related studies Functional annotation Related other genetic factors Overlap with SZ and MDD ADD to My Gene Set Comment on Gene View All Comments on Gene
Basic Info
Approved Symbol TSPAN8
Previous Symbol TM4SF3
Symbol Alias CO-029
Approved Name tetraspanin 8
Previous Name transmembrane 4 superfamily member 3
Location 12q14.1-q21.1
Position chr12:71125085-71441898, -1
External Links HGNC: 11855
Entrez Gene: 7103
Ensembl: ENSG00000127324
UCSC: uc001swj.1
No. of Studies 2 (Positive: 1; Negative: 0; trend: 1)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Sklar, P., 2008 SNP: rs1705236 Our strongest single SNP results are found in myosin5B (TSPAN8; P-value = 6.11E-07). Haplotype analysis further supported single SNP results highlighting TSPAN8 (P-value = 7.57E-07) Trend Comment on Study
Scholz, C. J.,2010 SNP: rs11178655, rs1397552, rs1705233, rs1705236, rs17109370, rs17226863, rs17849952, rs1796330, rs1798086, rs2270586, rs3763978, rs3794217, rs4500567, rs4760908
Haplotype: rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-A-G-C-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-G-C-C-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-G-G-C-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(A-G-G-G-G), rs1705236 - rs1798086 - rs17226863 - rs4500567 - rs1397552(T-G-G-C-A)		 This suggests that TSPAN8 contributes to both diseases. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 3)

GO terms by PBA (count: 1)

GO terms by database search (count: 2)


Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 77)

Literature-origin SNPs (count: 14)

LD-proxies (count: 63)


Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 1)


Gene relationship with MDD

View in gBrowse

Region: chr12:71125085..71441898 View in gBrowse
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Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback Acknowledgements
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Last update: March 31, 2016