Gene Report

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Basic Info

Approved Symbol	RNF144B
Previous Symbol	IBRDC2
Symbol Alias	bA528A10.3
Approved Name	ring finger protein 144B
Previous Name	IBR domain containing 2
Location	6p22.3
Position	chr6:18387350-18468874, 1
External Links	HGNC: 21578 Entrez Gene: 255488 Ensembl: ENSG00000137393 UCSC: uc003ncs.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Johnson, C.,2009		Monte-Carlo Simulation P-value = 0.0011. One of Genes That Harbor Overlapping Clusters of 4 Nominally Positive SNPs Whose Allele Frequencies Distinguish Individuals With Bipolar Disorder From Controls With P<0.05 Nominal Significance From at Least Three of the Four Samples in This Analysis	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0031966	mitochondrial membrane	cellular component	IDA[20300062]	3
GO:0004842	ubiquitin-protein transferase activity	molecular function	IDA[12853982]	12
GO:0016874	ligase activity	molecular function	IEA	16
GO:0005515	protein binding	molecular function	IPI[12853982]	563
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process	biological process	IDA[12853982]	4
GO:0000151	ubiquitin ligase complex	cellular component	IC[12853982]	4
GO:0006915	apoptotic process	biological process	IEA	39
GO:0005737	cytoplasm	cellular component	IDA[20300062]	322
GO:0008270	zinc ion binding	molecular function	IEA	77

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RNF144B	UBE2L6	NO	in vitro	16427630
RNF144B	CDKN1A	NO	in vitro;in vivo	12853982

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6p22	chr6:15200000-30500000	1 (0/1/0)
6p22.3	chr6:15200000-25200000	1 (0/1/0)
6p23-p21.1	chr6:13400000-46200000	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:18387350..18468874 View in gBrowse