Gene Report

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Basic Info

Approved Symbol	OR4X2
Approved Name	olfactory receptor, family 4, subfamily X, member 2 (gene/pseudogene)
Location	11p11.2
Position	chr11:48245056-48246080, 1
External Links	HGNC: 15184 Entrez Gene: 119764 Ensembl: ENSG00000172208 UCSC: uc001ngs.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs145684951	Amish-specific putative damaging exonic missense variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IBA	219
GO:0005886	plasma membrane	cellular component	TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004930	G-protein coupled receptor activity	molecular function	IEA	26
GO:0004984	olfactory receptor activity	molecular function	IEA	5
GO:0050911	detection of chemical stimulus involved in sensory perception of smell	biological process	IEA	5
GO:0050907	detection of chemical stimulus involved in sensory perception	biological process	IBA	2
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IBA	64
GO:0004888	transmembrane signaling receptor activity	molecular function	IBA	10

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04740	Olfactory transduction	11

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs145684951	chr11:48245690 - 48245690(1)	missense_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 11	chr11:0-135086622	2 (0/2/0)
11q14.3-11q21	chr11:22000000-97400000	1 (0/0/1)
11p11.2	chr11:43400000-48800000	1 (0/1/0)
11p11	chr11:43400000-53400000	1 (1/0/0)
11p13-q13.3	chr11:31000000-70500000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr11:48245056..48246080 View in gBrowse