Gene Report

Basic Info
Approved Symbol CSNK1E
Symbol Alias HCKIE, CKIE, CKIepsilon
Approved Name casein kinase 1, epsilon
Location 22q13.1
Position chr22:38290691-38398522, -1
External Links HGNC: 2453
Entrez Gene: 1454
Ensembl: ENSG00000213923
UCSC: uc003avk.3
No. of Studies 5 (Positive: 1; Negative: 3; trend: 1)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 5)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Byrne, E. M., 2014 P-value=0.83. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Mansour, H. A.,2009 SNP: rs1997644 Gene-based tests:X<sup>2</sup>=6.251, P-value = 0.098 in recessive model, X<sup>2</sup>=5.354, P-value = 0.14 in additive model, X<sup>2</sup>=3.728, P-value = 0.354 in dominant model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Soria, V.,2010 SNP: rs1997644 Significant associations of CSNK1E gene were found in BPD patients. Positive Comment on Study
Matsunaga, S.,2012 SNP: rs135745, rs135757, rs135764, rs1997644, rs2075984, rs3890379, rs6001093 None of the SNPs showed a significant association with MDD, but a SNP (rs2075984) in CSNK1E and SNP (rs6502097) in CSNK1D were associated with SCZ (P=0.0091, uncorrected) and BD (P=0.030, uncorrected), respectively. Negative Comment on Study
Nievergelt, C. M., 2006 Linkage analysis in 52 affected families showed suggestive evidence for linkage to CSNK1epsilon. This finding was not substantiated in the association study. Trend Comment on Study
Gene functional annotation
Gene related GO terms (count: 26)

GO terms by PBA (count: 3)

GO terms by database search (count: 23)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 18)

Related other genetic factors
Gene related SNPs (count: 15)

Literature-origin SNPs (count: 7)

LD-proxies (count: 8)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 3)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr22:38290691..38398522 View in gBrowse
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