Gene Report

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Basic Info

Approved Symbol	CHL1
Symbol Alias	CALL, L1CAM2, FLJ44930, MGC132578
Approved Name	cell adhesion molecule L1-like
Previous Name	cell adhesion molecule with homology to L1CAM (close homologue of L1), "cell adhesion molecule with homology to L1CAM (close homolog of L1)"
Name Alias	neural cell adhesion molecule, "close homolog of L1"
Location	3p26
Position	chr3:196596-409417, 1
External Links	HGNC: 1939 Entrez Gene: 10752 Ensembl: ENSG00000134121 UCSC: uc003bot.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IEA	360
GO:0007155	cell adhesion	biological process	IEA	42
GO:0007411	axon guidance	biological process	TAS	60
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0035640	exploration behavior	biological process	IEA	4
GO:0008344	adult locomotory behavior	biological process	IEA	15
GO:0050890	cognition	biological process	IEA	11
GO:0007165	signal transduction	biological process	TAS[9799093]	136
GO:0031103	axon regeneration	biological process	IEA	3
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0002020	protease binding	molecular function	IEA	10
GO:0030425	dendrite	cellular component	IEA	65
GO:0005578	proteinaceous extracellular matrix	cellular component	IEA	19
GO:0043524	negative regulation of neuron apoptotic process	biological process	IEA	26
GO:0045177	apical part of cell	cellular component	IEA	13
GO:0001764	neuron migration	biological process	IEA	18

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_25	chr3:38411-3305438 (NCBI Build 36/hg18)	3	3p26.3	deletion

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p24-p26	chr3:0-30800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr3:196596..409417 View in gBrowse