Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	DOCK9
Symbol Alias	KIAA1058, ZIZ1
Approved Name	dedicator of cytokinesis 9
Name Alias	zizimin1
Location	13q32.3
Position	chr13:98793429-99086625, -1
External Links	HGNC: 14132 Entrez Gene: 23348 Ensembl: ENSG00000088387 UCSC: uc001vnt.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Detera-Wadleigh, S. D., 2007	SNP: rs1028910, rs1041093, rs10492574, rs12428661, rs1299066, rs1324982, rs1340, rs1359427, rs1536657, rs1886553, rs1886554, rs1887856, rs1927568, rs2000342, rs2026024, rs2105425, rs2296983, rs2296994, rs2390129, rs2899, rs3858781, rs4772152, rs4772168, rs6491476, rs7328282, rs7331595, rs7333687, rs7334435, rs772303, rs772311, rs7986477, rs8002389, rs874199, rs9513550, rs9517549, rs9517575, rs9554547, rs9557134, rs9557137 Other variant: DOCK9_(AAGTA)_indel	This gene contributes to both risk and increased illness severity in bipolar disorder	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005089	Rho guanyl-nucleotide exchange factor activity	molecular function	IEA	7
GO:0017048	Rho GTPase binding	molecular function	IEA	4
GO:0016020	membrane	cellular component	IDA[19946888]	137

GO terms by database search (count: 7)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0043547	positive regulation of GTPase activity	biological process	IEA	30
GO:0007596	blood coagulation	biological process	TAS	44
GO:0005829	cytosol	cellular component	TAS	223
GO:0008150	biological_process	biological process	ND	24
GO:0012505	endomembrane system	cellular component	IEA	9
GO:0005515	protein binding	molecular function	IPI[18729074]	563
GO:0007264	small GTPase mediated signal transduction	biological process	IEA	18

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DOCK9	CDC42	NO	in vitro;in vivo	12172552

Related other genetic factors

Gene related SNPs (count: 39)

Literature-origin SNPs (count: 39)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1028910	chr13:98927474 - 98927474(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs2026024	chr13:98885177 - 98885177(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs2000342	chr13:99027593 - 99027593(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(1/0/0)
rs2296983	chr13:98804907 - 98804907(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs7331595	chr13:98945478 - 98945478(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs1927568	chr13:99087863 - 99087863(1)	non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)
rs2899	chr13:98793610 - 98793610(1)	3_prime_UTR_variant; NMD_transcript_variant	1(0/1/0)
rs772303	chr13:98800053 - 98800053(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs8002389	chr13:98955657 - 98955657(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs874199	chr13:98964853 - 98964853(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs2296994	chr13:98881643 - 98881643(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs4772168	chr13:99015728 - 99015728(1)	5_prime_UTR_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs1340	chr13:99088399 - 99088399(1)	non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(1/0/0)
rs6491476	chr13:99033850 - 99033850(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs1359427	chr13:98986154 - 98986154(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs1041093	chr13:99003403 - 99003403(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs1324982	chr13:98891879 - 98891879(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs2105425	chr13:99074311 - 99074311(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs12428661	chr13:98923314 - 98923314(1)	NMD_transcript_variant; synonymous_variant	1(0/1/0)
rs9513550	chr13:99100256 - 99100256(1)		1(1/0/0)
rs9557134	chr13:99076198 - 99076198(1)	intron_variant; NMD_transcript_variant	1(1/0/0)
rs7328282	chr13:98902701 - 98902701(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs1886554	chr13:99009826 - 99009826(1)	intron_variant; NMD_transcript_variant	1(1/0/0)
rs1887856	chr13:98827093 - 98827093(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs7333687	chr13:98838305 - 98838305(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant	1(0/1/0)
rs10492574	chr13:99044676 - 99044676(1)	intron_variant; NMD_transcript_variant	1(1/0/0)
rs1886553	chr13:98998484 - 98998484(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs1536657	chr13:99153166 - 99153166(1)		1(0/1/0)
rs2390129	chr13:98975826 - 98975826(1)	intron_variant; NMD_transcript_variant	1(1/0/0)
rs7334435	chr13:99079367 - 99079367(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs4772152	chr13:98869502 - 98869502(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs3858781	chr13:99105423 - 99105423(1)		1(0/1/0)
rs9517575	chr13:99057486 - 99057486(1)	intron_variant; NMD_transcript_variant	1(1/0/0)
rs9517549	chr13:99022126 - 99022126(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1299066	chr13:98780618 - 98780618(1)		1(0/1/0)
rs7986477	chr13:98847097 - 98847097(1)	5_prime_UTR_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs9557137	chr13:99084888 - 99084888(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant	1(1/0/0)
rs9554547	chr13:99064223 - 99064223(1)	intron_variant; NMD_transcript_variant	1(0/1/0)
rs772311	chr13:98816225 - 98816225(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
DOCK9_(AAGTA)_indel	insertion/deletion		1 (1/0/0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
13q32	chr13:98700000-101100000	9 (2/3/4)
13q21-33	chr13:54700000-109600000	1 (0/0/1)
13q22-32	chr13:72800000-101100000	1 (0/0/1)
13q31-q34	chr13:78500000-114364328	1 (0/0/1)
Chr 13	chr13:0-114364328	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr13:98793429..99086625 View in gBrowse