Gene Report

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Basic Info

Approved Symbol	RGS7
Approved Name	regulator of G-protein signaling 7
Previous Name	regulator of G-protein signalling 7
Location	1q43
Position	chr1:240775515-241357230, -1
External Links	HGNC: 10003 Entrez Gene: 6000 Ensembl: ENSG00000182901 UCSC: uc001hyv.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Bergen, S. E.,2012	SNP: rs984402	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IBA	360
GO:0004871	signal transducer activity	molecular function	IEA	32
GO:0005634	nucleus	cellular component	IEA	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005829	cytosol	cellular component	IEA	223
GO:0044292	dendrite terminus	cellular component	IEA	1
GO:0043547	positive regulation of GTPase activity	biological process	IBA	30
GO:0031681	G-protein beta-subunit binding	molecular function	IPI[19376773]	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64
GO:0005834	heterotrimeric G-protein complex	cellular component	IEA	6
GO:0035556	intracellular signal transduction	biological process	IEA	38
GO:0005096	GTPase activator activity	molecular function	IBA	19
GO:0038032	termination of G-protein coupled receptor signaling pathway	biological process	IEA	7
GO:0005737	cytoplasm	cellular component	IBA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
RGS7	SNAPIN	NO	in vitro;in vivo;yeast 2-hybrid	12659861
RGS7	GNAI3	NO	in vitro	10092682
RGS7	GNAO1	NO	in vitro	9572280
RGS7	PKD1	NO	in vitro;in vivo;yeast 2-hybrid	10339594
RGS7	YWHAB	NO	in vivo	10862767
RGS7	GNB5	NO	in vitro	10521509 , 10051672
RGS7	GNAQ	NO	in vitro;in vivo	12670932
RGS7	GNAI1	NO	in vitro	9572280
RGS7	PRKCA	NO	in vitro	12077120
RGS7	MSX1	NO	in vitro;in vivo	10862767
RGS7	YWHAQ	YES	in vitro;in vivo	10862767

Related other genetic factors

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs984402	chr1:240952383 - 240952383(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs12072679	chr1:240949874 - 240949874(1)	intron_variant
rs12143076	chr1:240962309 - 240962309(1)	intron_variant
rs12132113	chr1:240962447 - 240962447(1)	intron_variant
rs3912107	chr1:240962934 - 240962934(1)	intron_variant
rs12731839	chr1:240963316 - 240963316(1)	intron_variant
rs12119557	chr1:240968001 - 240968001(1)	intron_variant
rs3912106	chr1:240962690 - 240962690(1)	intron_variant
rs10802916	chr1:240968716 - 240968716(1)	intron_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Zhang[2009]_9	chr1:239069843-239226340 (Affymetrix SNP 6.0 array reference genome)	156497		Singleton deletions

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
22688191	No significant association was observed in SZ.	Negative

Gene relationship with MDD

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Region: chr1:240775515..241357230 View in gBrowse