Gene Report

Basic Info
Approved Symbol MAOB
Approved Name monoamine oxidase B
Location Xp11.4-p11.3
Position chrX:43766611-43882447, -1
External Links HGNC: 6834
Entrez Gene: 4129
Ensembl: ENSG00000069535
UCSC: uc004dfz.4
No. of Studies 4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Lim, L. C.,1995 Other variant: MAOB_(GT)n X<sup>2</sup> = 4.49, df = 5, P-value = 0.4814.. There was no difference in the distribution of alleles between patients and controls at the MAOB locus Negative Comment on Study
Muramatsu, T., 1997 Other variant: MAOB_(GT)n Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder. Negative Comment on Study
Lin, S.,2000 Other variant: MAOB_(GT)n As for association studies, significant association between bipolar disorder and MAOB gene was detected. Positive Comment on Study
Parsian, A., 1997 Other variant: MAOB_1-12 allele These data do not support the association of MAO-A or B with bipolar affective disorder but do demonstrate that undetected population stratification can be an important source of bias in case-control studies. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 25)

GO terms by PBA (count: 1)

GO terms by database search (count: 24)

Gene related KEGG pathways (count: 7)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 4)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Gene related regions (count: 1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chrX:43766611..43882447 View in gBrowse
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