Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	MAOB
Approved Name	monoamine oxidase B
Location	Xp11.4-p11.3
Position	chrX:43766611-43882447, -1
External Links	HGNC: 6834 Entrez Gene: 4129 Ensembl: ENSG00000069535 UCSC: uc004dfz.4
No. of Studies	4 (Positive: 2; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 4)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Lim, L. C.,1995	Other variant: MAOB_(GT)n	X<sup>2</sup> = 4.49, df = 5, P-value = 0.4814.. There was no difference in the distribution of alleles between patients and controls at the MAOB locus	Negative	Comment on Study
Muramatsu, T., 1997	Other variant: MAOB_(GT)n	Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder.	Negative	Comment on Study
Lin, S.,2000	Other variant: MAOB_(GT)n	As for association studies, significant association between bipolar disorder and MAOB gene was detected.	Positive	Comment on Study
Parsian, A., 1997	Other variant: MAOB_1-12 allele	These data do not support the association of MAO-A or B with bipolar affective disorder but do demonstrate that undetected population stratification can be an important source of bias in case-control studies.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 25)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0009636	response to toxic substance	biological process	IEA	12
GO:0051412	response to corticosterone	biological process	IEA	9
GO:0055114	oxidation-reduction process	biological process	IEA	43
GO:0050665	hydrogen peroxide biosynthetic process	biological process	NAS[24252804]	2
GO:0005740	mitochondrial envelope	cellular component	TAS[7063850]	2
GO:0032496	response to lipopolysaccharide	biological process	IEA	22
GO:0009055	electron carrier activity	molecular function	TAS[8602220]	5
GO:0010044	response to aluminum ion	biological process	IEA	2
GO:0008131	primary amine oxidase activity	molecular function	TAS	2
GO:0042493	response to drug	biological process	IEA	57
GO:0014063	negative regulation of serotonin secretion	biological process	IEA	1
GO:0006805	xenobiotic metabolic process	biological process	TAS	19
GO:0010269	response to selenium ion	biological process	IEA	3
GO:0050660	flavin adenine dinucleotide binding	molecular function	IEA	5
GO:0005743	mitochondrial inner membrane	cellular component	IEA	12
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:0021762	substantia nigra development	biological process	IEP[22926577]	7
GO:0005741	mitochondrial outer membrane	cellular component	TAS[24252804]	10
GO:0045964	positive regulation of dopamine metabolic process	biological process	IEA	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0005739	mitochondrion	cellular component	IDA[20833797]	75
GO:0045471	response to ethanol	biological process	IEA	24
GO:0042420	dopamine catabolic process	biological process	TAS[24252804]	5
GO:0044281	small molecule metabolic process	biological process	TAS	117

Gene related KEGG pathways (count: 7)

KEGG pathways by PBA (count: 3)

ID	Name	No. of Genes in BDgene
hsa00260	Glycine, serine and threonine metabolism	3
hsa00982	Drug metabolism - cytochrome P450	6
hsa00220	Urea cycle and metabolism of amino groups	4

KEGG pathways by database search (count: 4)

ID	Name	No. of Genes in BDgene
hsa00340	Histidine metabolism	6
hsa00360	Phenylalanine metabolism	3
hsa00350	Tyrosine metabolism	8
hsa00380	Tryptophan metabolism	9

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
MAOB_1-12 allele	others		1 (1/0/0)
MAOB_(GT)n	microsatellite		3 (1/2/0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Xp11.3	chrX:42500000-47600000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 7)

Reference	ID in SZGene	Result Category
10697823	44	Trend
18832861	44	Positive
19508883	44	Negative
15635698	44	Negative
8804132	44	Negative
18553363	44	Positive
20016224	44	Negative

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Reference	Description	Category in MDD
10686545	As for association studies, no significant association between unipolar disorder and MAOB gene was detected.	Negative
9342198	Therefore, our results did not support the involvement of the alleles at MAOA and MAOB in the etiology of mood disorder.	Negative

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chrX:43766611..43882447 View in gBrowse