Gene Report

Basic Info
Approved Symbol ARNTL2
Symbol Alias BMAL2, MOP9, CLIF, PASD9, bHLHe6
Approved Name aryl hydrocarbon receptor nuclear translocator-like 2
Location 12p12.2-p11.2
Position chr12:27332854-27425289, 1
External Links HGNC: 18984
Entrez Gene: 56938
Ensembl: ENSG00000029153
UCSC: uc001rhu.2
No. of Studies 3 (Positive: 1; Negative: 2; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 3)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Soria, V.,2010 SNP: rs10506018, rs10842905, rs11048994, rs11048995, rs11610949, rs2970844, rs35878285, rs3751222, rs4964060 Significant associations of ARNTL2 gene were found in BPD patients. Positive Comment on Study
Mansour, H. A.,2009 Gene-based tests:X<sup>2</sup>=4.067, P-value = 0.559 in recessive model, X<sup>2</sup>=4.068, P-value = 0.591 in dominant model, X<sup>2</sup>=3.171, P-value = 0.699 in additive model in BPI. No significant association was observed using neither single SNP-based analyses nor gene-based tests in BPI. Negative Comment on Study
Byrne, E. M., 2014 P-value=0.36. Gene-based tests show no significant association between this gene and BD. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 18)

GO terms by PBA (count: 3)

GO terms by database search (count: 15)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 19)

Literature-origin SNPs (count: 9)

LD-proxies (count: 10)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 2)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 0)

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Region: chr12:27332854..27425289 View in gBrowse
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