Gene Report

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Basic Info

Approved Symbol	ZNF274
Symbol Alias	ZKSCAN19, ZSCAN51
Approved Name	zinc finger protein 274
Location	19q13.43
Position	chr19:58183029-58213562, 1
External Links	HGNC: 13068 Entrez Gene: 10782 Ensembl: ENSG00000171606 UCSC: uc032igq.1
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00005, Product of P truncation <=0.01=0.00005, Product of P truncation <=0.001=0.00005. It showed evidence for association with BD.	Positive	Comment on Study
Xu, W., 2014	SNP: rs4444432, rs7256349	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66
GO:0005634	nucleus	cellular component	IDA	283
GO:0003714	transcription corepressor activity	molecular function	TAS[10777669]	21
GO:0043565	sequence-specific DNA binding	molecular function	IDA[21170338]	29

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005730	nucleolus	cellular component	IEA	28
GO:0006351	transcription, DNA-templated	biological process	IEA	103
GO:1903507	negative regulation of nucleic acid-templated transcription	biological process	TAS[10777669]	2
GO:0005515	protein binding	molecular function	IPI[21170338]	563
GO:0006355	regulation of transcription, DNA-templated	biological process	IEA	62
GO:0005813	centrosome	cellular component	IDA	34
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0005654	nucleoplasm	cellular component	IDA	163

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ZNF274	NGFR	NO	in vitro;in vivo	10545116

Related other genetic factors

Gene related SNPs (count: 9)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7256349	chr19:58206902 - 58206902(1)	downstream_gene_variant; missense_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs1483651	chr19:58178467 - 58178467(1)	upstream_gene_variant	1(0/1/0)
rs4444432	chr19:58204171 - 58204171(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)
rs7248493	chr19:58199741 - 58199741(1)	intron_variant; non_coding_transcript_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs12975369	chr19:58182051 - 58182051(1)	upstream_gene_variant
rs12982863	chr19:58204051 - 58204051(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs7250280	chr19:58202407 - 58202407(1)	intron_variant; non_coding_transcript_exon_variant; non_coding_transcript_variant
rs11672645	chr19:58207332 - 58207332(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant
rs2062251	chr19:58204315 - 58204315(1)	downstream_gene_variant; intron_variant; non_coding_transcript_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
19p13-q13	chr19:0-58617616	1 (0/1/0)
Chr 19	chr19:0-58617616	2 (0/2/0)
19q13	chr19:31900000-58617616	2 (0/2/0)
19q13.33-qter	chr19:47500000-58617616	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

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Region: chr19:58183029..58213562 View in gBrowse