Gene Report

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Basic Info

Approved Symbol	SYPL1
Previous Symbol	SYPL
Approved Name	synaptophysin-like 1
Previous Name	synaptophysin-like protein
Location	7q22.2
Position	chr7:106090503-106112576, -1
External Links	HGNC: 11507 Entrez Gene: 6856 Ensembl: ENSG00000008282 UCSC: uc003vdp.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Chen, X., 2015		SYPL1 has been implicated in MDD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	TAS[1730063]	219
GO:0007268	synaptic transmission	biological process	TAS[8034131]	116
GO:0005887	integral component of plasma membrane	cellular component	TAS[8034131]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008021	synaptic vesicle	cellular component	IEA	13
GO:0042470	melanosome	cellular component	IEA	15
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0030659	cytoplasmic vesicle membrane	cellular component	IEA	12
GO:0030285	integral component of synaptic vesicle membrane	cellular component	IBA	1
GO:0030141	secretory granule	cellular component	IEA	14
GO:0005215	transporter activity	molecular function	IEA	8
GO:0006810	transport	biological process	IEA	47

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SYPL1	VAMP2	YES	in vivo	10370136

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
7q22.3	chr7:104900000-107800000	1 (1/0/0)
7q21-31	chr7:77900000-127500000	1 (1/0/0)
7q22	chr7:98400000-107800000	1 (0/1/0)
Chr 7	chr7:0-159345973	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

Reference	Description	Category in MDD	Link in MK4MDD
17938633	Selected differentially expressed genes in BA44 to BA47 (ANOVA and t-test P < 0.01, fold change 1.3t)	Pos	SYPL1

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Region: chr7:106090503..106112576 View in gBrowse