Gene Report

Basic Info
Approved Symbol SLC18A2
Previous Symbol VMAT2
Symbol Alias SVMT, SVAT
Approved Name solute carrier family 18 (vesicular monoamine transporter), member 2
Location 10q25
Position chr10:117241093-117279430, 1
External Links HGNC: 10935
Entrez Gene: 6571
Ensembl: ENSG00000165646
UCSC: uc001ldd.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Gutierrez, B., 2007 SNP: rs363272, rs363343, rs363387, rs363420
Haplotype: rs363387 - rs363343 - rs363272(T-A-G), rs363387 - rs363343 - rs363272(C-C-A), rs363387 - rs363343 - rs363272(T-C-A), rs363387 - rs363343 - rs363272(C-A-G), rs363387 - rs363420 - rs363272(), rs363387 - rs363420 - rs363343(), rs363387 - rs363420 - rs363343 - rs363272(), rs363420 - rs363272(), rs363420 - rs363343(), rs363420 - rs363343 - rs363272()
SVMT gene or certain regions of it may constitute a genetic substrate of susceptibility for both schizophrenia and bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 41)

GO terms by PBA (count: 4)

GO terms by database search (count: 37)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Related other genetic factors
Gene related SNPs (count: 26)

Literature-origin SNPs (count: 4)

LD-proxies (count: 22)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr10:117241093..117279430 View in gBrowse
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