Gene Report

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Basic Info

Approved Symbol	DPP6
Symbol Alias	DPPX
Approved Name	dipeptidyl-peptidase 6
Previous Name	dipeptidylpeptidase VI, "dipeptidylpeptidase 6"
Location	7q36.2
Position	chr7:153887097-154894285, 1
External Links	HGNC: 3010 Entrez Gene: 1804 Ensembl: ENSG00000130226 UCSC: uc003wlk.3
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Noor A., 2014		Selected stringent CNV related to this gene is validated by qPCR from BD case data.	Positive	Comment on Study
Djurovic, S.,2010	SNP: rs1979601, rs4960568	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008076	voltage-gated potassium channel complex	cellular component	IDA[18364354]	8
GO:0008239	dipeptidyl-peptidase activity	molecular function	IDA[8103397]	3
GO:0005886	plasma membrane	cellular component	ISS	360
GO:0016021	integral component of membrane	cellular component	IDA[18364354]	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0072659	protein localization to plasma membrane	biological process	ISS	9
GO:0008236	serine-type peptidase activity	molecular function	IEA	9
GO:0006508	proteolysis	biological process	IEA	34
GO:0015459	potassium channel regulator activity	molecular function	IDA[18364354]; ISS	11
GO:1901379	regulation of potassium ion transmembrane transport	biological process	IDA[18364354]; ISS	4
GO:1901381	positive regulation of potassium ion transmembrane transport	biological process	IEA	1
GO:0019228	neuronal action potential	biological process	IEA	11
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DPP6	PRNP	NO	in vivo	15146195

Related other genetic factors

Gene related SNPs (count: 11)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4960568	chr7:154639123 - 154639123(1)	intron_variant	1(0/1/0)
rs10901040	chr7:154638563 - 154638563(1)	intron_variant	1(0/1/0)
rs1979601	chr7:154639470 - 154639470(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs6972501	chr7:154637947 - 154637947(1)	intron_variant
rs11243339	chr7:154637850 - 154637850(1)	intron_variant; synonymous_variant
rs11243338	chr7:154637485 - 154637485(1)	intron_variant
rs6961341	chr7:154638321 - 154638321(1)	intron_variant
rs7800390	chr7:154637231 - 154637231(1)	intron_variant
rs7800130	chr7:154637098 - 154637098(1)	intron_variant
rs6968015	chr7:154637442 - 154637442(1)	intron_variant
rs7800584	chr7:154637373 - 154637373(1)	intron_variant

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Abdul Noor[2014]_11	chr7:152925592-153338318 (NCBI Build 36/hg18)	412000	7q36.2	duplication

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)
7q36	chr7:148200000-159345973	3 (0/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr7:153887097..154894285 View in gBrowse