Gene Report

Basic Info
Approved Symbol HSP90B1
Previous Symbol TRA1
Symbol Alias GP96, GRP94
Approved Name heat shock protein 90kDa beta (Grp94), member 1
Previous Name tumor rejection antigen (gp96) 1
Location 12q24.2-q24.3
Position chr12:103930107-103953645, 1
External Links HGNC: 12028
Entrez Gene: 7184
Ensembl: ENSG00000166598
UCSC: uc001tkb.2
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kakiuchi, C., 2007 (a) SNP: rs1165670, rs1165678, rs1165681, rs1165687, rs17034977, rs1882019, rs2070908, rs2293618, rs3794241, rs6615, rs703657
Haplotype: rs1165687 - rs1882019 - rs17034977 - rs703657 - rs2293618(C-A-A-T-T), rs1165687 - rs1882019 - rs17034977 - rs703657 - rs2293618(C-G-A-A-C), rs1165687 - rs1882019 - rs17034977 - rs703657 - rs2293618(C-G-C-T-T)
expression levels of HSP90B1 to GAPDH in the cells, Mann-Whitney U test, P-value = 0.468. HSP90B1 may have a pathophysiological role in bipolar disorder in the Japanese population; Gene expression analysis of HSP90B1 in lymphoblastoid cells suggested a possible relationship between the associated SNP and mRNA levels. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 38)

GO terms by PBA (count: 6)

GO terms by database search (count: 32)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 11)

Related other genetic factors
Gene related SNPs (count: 48)

Literature-origin SNPs (count: 11)

LD-proxies (count: 37)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

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Region: chr12:103930107..103953645 View in gBrowse
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