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Gene Report
| Basic information | Related studies | Functional annotation | Related other genetic factors | Overlap with SZ and MDD | ADD to My Gene Set | Comment on Gene | View All Comments on Gene |
| Approved Symbol | LNX1 |
|---|---|
| Previous Symbol | LNX |
| Symbol Alias | MPDZ, PDZRN2 |
| Approved Name | ligand of numb-protein X 1, E3 ubiquitin protein ligase |
| Previous Name | ligand of numb-protein X, "ligand of numb-protein X 1" |
| Location | 4q12 |
| Position | chr4:53459301-53701405, -1 |
| External Links |
HGNC: 6657 Entrez Gene: 84708 Ensembl: ENSG00000072201 UCSC: uc003hag.5 |
| No. of Studies | 1 (Positive: 1; Negative: 0; trend: 0) |
| Overlap with SZ? | NO |
| Overlap with MDD? | NO |
Gene related studies (count: 1)
| Reference | Tested Markers | Statistical Values/Author Comments | Result Category | Comment on Study |
|---|---|---|---|---|
| Ross, K. A.,2011 | Other variant: LNX1_SNP A-1948953 | Significant associations of LNX1 SNP A-1948953 were found in BPD patients.LNX1 SNP A-1948953 | Positive | Comment on Study |
Gene functional annotation
Gene related GO terms (count: 8)
GO terms by PBA (count: 1)
| ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
|---|---|---|---|---|
| GO:0030165 | PDZ domain binding | molecular function | IEA | 16 |
GO terms by database search (count: 7)
| ID | Name | Type | Evidence[PMID] | No. of Genes in BDgene |
|---|---|---|---|---|
| GO:0005515 | protein binding | molecular function | IPI[16002321] | 563 |
| GO:0004842 | ubiquitin-protein transferase activity | molecular function | IEA | 12 |
| GO:0016874 | ligase activity | molecular function | IEA | 16 |
| GO:0042787 | protein ubiquitination involved in ubiquitin-dependent protein catabolic process | biological process | IEA | 4 |
| GO:0008270 | zinc ion binding | molecular function | IEA | 77 |
| GO:0005737 | cytoplasm | cellular component | IEA | 322 |
| GO:0051260 | protein homooligomerization | biological process | IEA | 13 |
Gene related KEGG pathways (count: 0)
Gene related BioCarta pathways (count: 0)
Gene related interactors from protein-protein interactions data in HPRD (count: 46)
| Gene | Interactor | Interactor in BDgene? | Experiment Type | PMID |
|---|---|---|---|---|
| LNX1 | LNX2 | NO | in vitro | 11922143 |
| LNX1 | DVL3 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | DCTD | NO | yeast 2-hybrid | 16189514 |
| LNX1 | APIP | NO | yeast 2-hybrid | 16189514 |
| LNX1 | DDX17 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | IGSF5 | NO | in vitro;in vivo;yeast 2-hybrid | 16832352 |
| LNX1 | TSC22D4 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | ENOX1 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | AIMP2 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | ZBTB43 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | RABAC1 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | PAFAH1B3 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | TRAF2 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | NAGK | NO | yeast 2-hybrid | 16189514 |
| LNX1 | TRIM23 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | CXADR | NO | in vitro;yeast 2-hybrid | 12468544 |
| LNX1 | PAICS | NO | yeast 2-hybrid | 16189514 |
| LNX1 | RAD54B | NO | yeast 2-hybrid | 16189514 |
| LNX1 | COIL | NO | yeast 2-hybrid | 16713569 |
| LNX1 | KHDRBS3 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | RBMX | NO | yeast 2-hybrid | 16189514 |
| LNX1 | CALCOCO2 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | KCTD13 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | SFRS1 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | RPIA | NO | yeast 2-hybrid | 16189514 |
| LNX1 | MAGEB18 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | CCDC85B | NO | yeast 2-hybrid | 16189514 |
| LNX1 | $ZBTB8$ | NO | yeast 2-hybrid | 16189514 |
| LNX1 | FHL3 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | AKIRIN2 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | TRIP13 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | LDOC1 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | KRTAP4-12 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | TIFA | NO | yeast 2-hybrid | 16189514 |
| LNX1 | KCTD17 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | MAGEA11 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | SAT1 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | FBP1 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | C19orf50 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | KLHL12 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | NECAB2 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | NADK | NO | yeast 2-hybrid | 16189514 |
| LNX1 | KRT15 | NO | yeast 2-hybrid | 16189514 |
| LNX1 | CUTC | NO | yeast 2-hybrid | 16189514 |
| LNX1 | EHMT2 | YES | yeast 2-hybrid | 16189514 |
| LNX1 | PCBD1 | NO | yeast 2-hybrid | 16189514 |
Related other genetic factors
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variants (count: 1)
| Variant Name | Variant Type | Location in Gene | No. of Studies (Positive/Negative/Trend)  |
|---|---|---|---|
| LNX1_SNP A-1948953 | point mutation | 1 (1/0/0) |
Gene related regions (count: 4)
| Region Name | Position | No. of Studies (Positive/Negative/Trend) |
|---|---|---|
| 4q12 | chr4:51800000-58500000 | 1 (0/1/0) |
| Chr 4 | chr4:0-190214555 | 3 (0/3/0) |
| 4q12-q21 | chr4:51800000-87100000 | 1 (0/0/1) |
| 4q12-q13 | chr4:51800000-75300000 | 1 (0/1/0) |
Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
View in gBrowse
Region: chr4:53459301..53701405 View in gBrowse
Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
Acknowledgements
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Last update: March 31, 2016