Gene Report

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Basic Info

Approved Symbol	FABP3
Previous Symbol	MDGI, FABP11
Symbol Alias	H-FABP, O-FABP
Approved Name	fatty acid binding protein 3, muscle and heart
Previous Name	fatty acid binding protein 11, "fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)"
Name Alias	mammary-derived growth inhibitor
Location	1p33-p32
Position	chr1:31365625-31376850, -1
External Links	HGNC: 3557 Entrez Gene: 2170 Ensembl: ENSG00000121769 UCSC: uc001bss.1
No. of Studies	2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.01657, Product of P truncation <=0.01=0.00075, Product of P truncation <=0.001=NA. It showed evidence for association with BD.	Positive	Comment on Study
Iwayama, Y., 2010	SNP: rs10914367, rs11436, rs12562824, rs3766293, rs3795432, rs6425744, rs6663779, rs7532813	FABP3 displayed no association with bipolar disorder.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008092	cytoskeletal protein binding	molecular function	IPI[17987659]	6

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005829	cytosol	cellular component	TAS[23873799]	223
GO:0032868	response to insulin	biological process	IEA	10
GO:0042632	cholesterol homeostasis	biological process	ISS	8
GO:0005515	protein binding	molecular function	IPI[20802519]	563
GO:0042493	response to drug	biological process	IEA	57
GO:0070542	response to fatty acid	biological process	IEA	3
GO:0071073	positive regulation of phospholipid biosynthetic process	biological process	IC[3421901]	1
GO:0006631	fatty acid metabolic process	biological process	IEA	6
GO:0036041	long-chain fatty acid binding	molecular function	IDA[3421901]	1
GO:0008285	negative regulation of cell proliferation	biological process	TAS[7962070]	41
GO:0070538	oleic acid binding	molecular function	IDA[3421901]	1
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0050543	icosatetraenoic acid binding	molecular function	IEA	1
GO:0016528	sarcoplasm	cellular component	IEA	2
GO:0005615	extracellular space	cellular component	IDA[16502470]	85
GO:0005324	long-chain fatty acid transporter activity	molecular function	IEA	1
GO:0046320	regulation of fatty acid oxidation	biological process	ISS	2
GO:0055091	phospholipid homeostasis	biological process	ISS	3
GO:0044539	long-chain fatty acid import	biological process	ISS	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa03320	PPAR signaling pathway	4

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
FABP3	TNNI3K	NO	yeast 2-hybrid	12721663
FABP3	VPS28	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 18)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs11436	chr1:31364473 - 31364473(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs12562824	chr1:31382035 - 31382035(1)		1(0/1/0)
rs10914367	chr1:31373359 - 31373359(1)	intron_variant; upstream_gene_variant	1(0/1/0)
rs3795432	chr1:31357026 - 31357026(1)	intron_variant	1(0/1/0)
rs3766293	chr1:31364349 - 31364349(1)	3_prime_UTR_variant; downstream_gene_variant	1(0/1/0)
rs7532813	chr1:31355410 - 31355410(1)	intron_variant	1(0/1/0)
rs6663779	chr1:31362680 - 31362680(1)	downstream_gene_variant; intron_variant	1(0/1/0)
rs6425744	chr1:31377810 - 31377810(1)	upstream_gene_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs4949391	chr1:31360859 - 31360859(1)	downstream_gene_variant; intron_variant
rs2279885	chr1:31372839 - 31372839(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs12401792	chr1:31374572 - 31374572(1)	intron_variant; upstream_gene_variant
rs10914368	chr1:31375090 - 31375090(1)	intron_variant; upstream_gene_variant
rs16834408	chr1:31365095 - 31365095(1)	downstream_gene_variant
rs4949393	chr1:31379028 - 31379028(1)	upstream_gene_variant
rs3766294	chr1:31364327 - 31364327(1)	3_prime_UTR_variant; downstream_gene_variant
rs951545	chr1:31371818 - 31371818(1)	intron_variant; NMD_transcript_variant; upstream_gene_variant
rs2271072	chr1:31367579 - 31367579(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant
rs7532845	chr1:31368772 - 31368772(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p35-p36	chr1:0-34300000	1 (1/0/0)
1p33-p36	chr1:0-50200000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative
19554614	FABP3 displayed no association with schizophrenia.	Negative

Reference	ID in SZGene	Result Category
20057506	813	Negative
19554614	813	Negative

Gene relationship with MDD

View in gBrowse

Region: chr1:31365625..31376850 View in gBrowse