Gene Report

Approved Symbol	TSNAX
Symbol Alias	TRAX
Approved Name	translin-associated factor X
Location	1q42.2
Position	chr1:231528653-231566524, 1
External Links	HGNC: 12380 Entrez Gene: 7257 Ensembl: ENSG00000116918 UCSC: uc001huw.3
No. of Studies	4 (Positive: 3; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Okuda, A.,2010	SNP: rs1630250, rs6662926, rs766288 Haplotype: rs1630250 - rs766288 - rs6662926(C-C-G), rs1630250 - rs766288 - rs6662926(C-T-G), rs1630250 - rs766288 - rs6662926(G-C-C)	We did not find any association between TSNAX and BP in the allele/genotype analysis or haplotype analysis.	Negative	Comment on Study
Palo, O. M., 2007	SNP: rs1615409, rs1630250, rs1655285 Haplotype: rs1615409 - rs1655285(C-G), rs1630250 - rs1615409(G-C), rs1630250 - rs1615409 - rs1655285(G-C-G), rs1615409 - rs1655285 - rs751229(C-G-T), rs1655285 - rs751229(G-T), rs1655285 - rs751229 - rs3738401(G-T-A)	The results provide evidence for an association of distinct allelic variants of TSNAX to psychotic and bipolar spectrum disorders	Positive	Comment on Study
Ram Murthy, A., 2012	SNP: rs766288 Haplotype: rs766288 - rs3738401 - rs2812393 - rs821616(C-G-G-T), rs766288 - rs3738401 - rs2812393 - rs821616(A-G-G-T), rs766288 - rs821616(C-A), rs766288 - rs821616(A-A), rs766288 - rs821616(C-T), rs766288 - rs821616(A-T), rs766288 - rs2812393(C-C), rs766288 - rs2812393(A-G), rs766288 - rs2812393(C-G ), rs766288 - rs2812393(A-C )	Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of SCZ and BPAD.	Positive	Comment on Study
Schosser, A., 2010	SNP: rs766288 Haplotype: rs766288 - rs2492367(AC)	We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD	Positive	Comment on Study

Region: chr1:231528653..231566524 View in gBrowse