Gene Report

Basic Info
Approved Symbol TSNAX
Symbol Alias TRAX
Approved Name translin-associated factor X
Location 1q42.2
Position chr1:231528653-231566524, 1
External Links HGNC: 12380
Entrez Gene: 7257
Ensembl: ENSG00000116918
UCSC: uc001huw.3
No. of Studies 4 (Positive: 3; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 4)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Okuda, A.,2010 SNP: rs1630250, rs6662926, rs766288
Haplotype: rs1630250 - rs766288 - rs6662926(C-C-G), rs1630250 - rs766288 - rs6662926(C-T-G), rs1630250 - rs766288 - rs6662926(G-C-C)
We did not find any association between TSNAX and BP in the allele/genotype analysis or haplotype analysis. Negative Comment on Study
Palo, O. M., 2007 SNP: rs1615409, rs1630250, rs1655285
Haplotype: rs1615409 - rs1655285(C-G), rs1630250 - rs1615409(G-C), rs1630250 - rs1615409 - rs1655285(G-C-G), rs1615409 - rs1655285 - rs751229(C-G-T), rs1655285 - rs751229(G-T), rs1655285 - rs751229 - rs3738401(G-T-A)
The results provide evidence for an association of distinct allelic variants of TSNAX to psychotic and bipolar spectrum disorders Positive Comment on Study
Ram Murthy, A., 2012 SNP: rs766288
Haplotype: rs766288 - rs3738401 - rs2812393 - rs821616(C-G-G-T), rs766288 - rs3738401 - rs2812393 - rs821616(A-G-G-T), rs766288 - rs821616(C-A), rs766288 - rs821616(A-A), rs766288 - rs821616(C-T), rs766288 - rs821616(A-T), rs766288 - rs2812393(C-C), rs766288 - rs2812393(A-G), rs766288 - rs2812393(C-G ), rs766288 - rs2812393(A-C )
Our results provide further evidence for sex-dependent effects of the TSNAX/DISC1 locus in the aetiology of SCZ and BPAD. Positive Comment on Study
Schosser, A., 2010 SNP: rs766288
Haplotype: rs766288 - rs2492367(AC)
We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 19)

GO terms by PBA (count: 5)

GO terms by database search (count: 14)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 9)

Related other genetic factors
Gene related SNPs (count: 37)

Literature-origin SNPs (count: 32)

LD-proxies (count: 5)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 8)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr1:231528653..231566524 View in gBrowse
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