Gene Report

Basic Info
Approved Symbol PRKCZ
Symbol Alias PKC2
Approved Name protein kinase C, zeta
Location 1p36.33-p36.2
Position chr1:2050470-2185395, 1
External Links HGNC: 9412
Entrez Gene: 5590
Ensembl: ENSG00000067606
UCSC: uc001aiq.3
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Kandaswamy, R.,2012 SNP: rs12132341, rs12134873, rs2503706, rs262641, rs262683, rs262688, rs3107146, rs3107156, rs3107157, rs3128296, rs3128309, rs3753242, rs384726, rs385039, rs626479, rs7513222, rs908742
Haplotype: rs3128296 - rs2503706(), rs2503706 - rs3128309(), rs3128296 - rs3128309(), rs3128296 - rs2503706 - rs3128309()
Other variant: PRKCZ(AC)24, PRKCZ(GT)17, D1S243, PRKCZ(CA)13
In the present study, we show nominally significant associations between genetic markers in the PRKCZ gene and bipolar affective disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 73)

GO terms by PBA (count: 7)

GO terms by database search (count: 66)

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 1)

KEGG pathways by database search (count: 2)

Gene related BioCarta pathways (count: 1)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 1)

Gene related interactors from protein-protein interactions data in HPRD (count: 64)

Related other genetic factors
Gene related SNPs (count: 78)

Literature-origin SNPs (count: 17)

LD-proxies (count: 61)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 5)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr1:2050470..2185395 View in gBrowse
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