Gene Report

Approved Symbol	SYNE1
Previous Symbol	C6orf98
Symbol Alias	SYNE-1B, KIAA0796, 8B, Nesprin-1, enaptin, MYNE1, CPG2, dJ45H2.2, SCAR8, ARCA1, Nesp1
Approved Name	spectrin repeat containing, nuclear envelope 1
Previous Name	chromosome 6 open reading frame 98
Name Alias	myocyte nuclear envelope protein 1, "nuclear envelope spectrin repeat-1"
Location	6q25.2
Position	chr6:152121684-152637801, -1
External Links	HGNC: 17089 Entrez Gene: 23345 Ensembl: ENSG00000131018 UCSC: uc003qou.4
No. of Studies	6 (Positive: 3; Negative: 2; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs7747960	No significant association of this gene was observed in BD.	Negative	Comment on Study
Green EK, 2013	SNP: rs9371601	Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders.	Positive	Comment on Study
Xu, W., 2014	SNP: rs2141150, rs214950, rs214972, rs215006, rs2623966, rs2623971, rs2695261, rs548978	6 SNPs within the gene SYNE1 on 6q25, with lowest p = 3.02E-6	Negative	Comment on Study
Green, E. K.,2012	SNP: rs9371601	BD ImmunoChip:P-value = 0.0764,OR = 0.916;ImmunoChip, PGC-BD combined data:P-balue = 0.000000138,OR = 0.911 Suggestive association was found.	Trend	Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013	SNP: rs9371601	Significant association was observed in BPD.	Positive	Comment on Study
Sklar, P.,2011	SNP: rs9371601	Significant association was found .	Positive	Comment on Study

Region: chr6:152121684..152637801 View in gBrowse