Gene Report

Basic Info
Approved Symbol SYNE1
Previous Symbol C6orf98
Symbol Alias SYNE-1B, KIAA0796, 8B, Nesprin-1, enaptin, MYNE1, CPG2, dJ45H2.2, SCAR8, ARCA1, Nesp1
Approved Name spectrin repeat containing, nuclear envelope 1
Previous Name chromosome 6 open reading frame 98
Name Alias myocyte nuclear envelope protein 1, "nuclear envelope spectrin repeat-1"
Location 6q25.2
Position chr6:152121684-152637801, -1
External Links HGNC: 17089
Entrez Gene: 23345
Ensembl: ENSG00000131018
UCSC: uc003qou.4
No. of Studies 6 (Positive: 3; Negative: 2; trend: 1)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 6)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Smith, E. N.,2011 SNP: rs7747960 No significant association of this gene was observed in BD. Negative Comment on Study
Green EK, 2013 SNP: rs9371601 Our findings add to the evidence that association at this locus influences susceptibility to bipolar and unipolar mood disorders. Positive Comment on Study
Xu, W., 2014 SNP: rs2141150, rs214950, rs214972, rs215006, rs2623966, rs2623971, rs2695261, rs548978 6 SNPs within the gene SYNE1 on 6q25, with lowest p = 3.02E-6 Negative Comment on Study
Green, E. K.,2012 SNP: rs9371601 BD ImmunoChip:P-value = 0.0764,OR = 0.916;ImmunoChip, PGC-BD combined data:P-balue = 0.000000138,OR = 0.911 Suggestive association was found. Trend Comment on Study
Cross-Disorder Group of the Psychiatric Genomics Consortium,2013 SNP: rs9371601 Significant association was observed in BPD. Positive Comment on Study
Sklar, P.,2011 SNP: rs9371601 Significant association was found . Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 24)

GO terms by PBA (count: 5)

GO terms by database search (count: 19)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Related other genetic factors
Gene related SNPs (count: 106)

Literature-origin SNPs (count: 10)

LD-proxies (count: 96)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 0)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 2)

Overlap with MDD from candidate gene intersection analysis (count: 1)

View in gBrowse

Region: chr6:152121684..152637801 View in gBrowse
View in gBrowse