Gene Report

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Basic Info

Approved Symbol	RBMS3
Approved Name	RNA binding motif, single stranded interacting protein 3
Previous Name	RNA binding motif, single stranded interacting protein
Name Alias	RNA-binding protein
Location	3p24-p23
Position	chr3:28574791-30010391, 1
External Links	HGNC: 13427 Entrez Gene: 27303 Ensembl: ENSG00000144642 UCSC: uc003cel.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs9819616	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 4)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003730	mRNA 3'-UTR binding	molecular function	IEA	4

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:0045727	positive regulation of translation	biological process	IEA	4
GO:0005737	cytoplasm	cellular component	IEA	322

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs7610043	chr3:29346140 - 29346140(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs9819616	chr3:30299934 - 30299934(1)	downstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
3p24	chr3:16300000-30800000	1 (0/1/0)
Chr 3	chr3:0-198295559	2 (0/2/0)
3p24-p26	chr3:0-30800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	Suggestive association was found with MDD.	Trend

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Region: chr3:28574791..30010391 View in gBrowse