Gene Report

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Basic Info

Approved Symbol	CPEB1
Symbol Alias	FLJ13203, CPEB
Approved Name	cytoplasmic polyadenylation element binding protein 1
Location	15q25.1
Position	chr15:82543201-82648861, -1
External Links	HGNC: 21744 Entrez Gene: 64506 Ensembl: ENSG00000214575 UCSC: uc002biv.4
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Drago, A., 2016		Freq(Significant SNPs/total SNPs%)=0.38. Encodes for a sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045211	postsynaptic membrane	cellular component	IEA	68
GO:0005634	nucleus	cellular component	ISS	283

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0072687	meiotic spindle	cellular component	IEA	1
GO:0000900	translation repressor activity, nucleic acid binding	molecular function	ISS	1
GO:0035925	mRNA 3'-UTR AU-rich region binding	molecular function	ISS	1
GO:0000166	nucleotide binding	molecular function	IEA	17
GO:2000766	negative regulation of cytoplasmic translation	biological process	IMP[18752464]	1
GO:0030054	cell junction	cellular component	IEA	88
GO:0006397	mRNA processing	biological process	IEA	8
GO:0005737	cytoplasm	cellular component	ISS	322
GO:0048168	regulation of neuronal synaptic plasticity	biological process	IEA	6
GO:0071230	cellular response to amino acid stimulus	biological process	ISS	6
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0007130	synaptonemal complex assembly	biological process	IEA	1
GO:0071456	cellular response to hypoxia	biological process	IDA[18752464]	13
GO:0014069	postsynaptic density	cellular component	IEA	26
GO:0032869	cellular response to insulin stimulus	biological process	IDA[18752464]	12
GO:0030425	dendrite	cellular component	IEA	65
GO:0000932	cytoplasmic mRNA processing body	cellular component	IEA	3

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 3)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CPEB1	MAP2	NO	in vitro;in vivo	12629046
CPEB1	DYNLRB1	YES	in vitro;in vivo	12629046
CPEB1	KIF1B	NO	in vitro;in vivo	12629046

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
15q25-26	chr15:78000000-101991189	1 (1/0/0)
15q24.1-25.2	chr15:72400000-84700000	1 (0/1/0)
Chr 15	chr15:0-101991189	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr15:82543201..82648861 View in gBrowse