Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	DLG3
Symbol Alias	NE-Dlg, SAP102, SAP-102, NEDLG, KIAA1232, MRX90, PPP1R82
Approved Name	discs, large homolog 3 (Drosophila)
Previous Name	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
Name Alias	neuroendocrine-dlg, "protein phosphatase 1, regulatory subunit 82"
Location	Xq13.1
Position	chrX:70444861-70505490, 1
External Links	HGNC: 2902 Entrez Gene: 1741 Ensembl: ENSG00000082458 UCSC: uc004dyi.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014		SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as the synapseassociated protein 102 gene, DLG3 (p = 5.31Ã—10-5).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 30)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030165	PDZ domain binding	molecular function	IEA	16
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0007399	nervous system development	biological process	IBA	40
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0007268	synaptic transmission	biological process	IBA; TAS	116
GO:0007411	axon guidance	biological process	TAS	60

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	biological process	IBA	3
GO:0043198	dendritic shaft	cellular component	IEA	7
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0019902	phosphatase binding	molecular function	IDA[19389623]	9
GO:0008328	ionotropic glutamate receptor complex	cellular component	IBA	6
GO:0004385	guanylate kinase activity	molecular function	IBA	3
GO:0001736	establishment of planar polarity	biological process	IEA	3
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	cellular component	IEA	8
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0097120	receptor localization to synapse	biological process	IBA	5
GO:0030426	growth cone	cellular component	IEA	22
GO:0043113	receptor clustering	biological process	IBA	8
GO:0008022	protein C-terminus binding	molecular function	IEA	21
GO:0031625	ubiquitin protein ligase binding	molecular function	IEA	25
GO:0010923	negative regulation of phosphatase activity	biological process	IDA[19389623]	5
GO:0035255	ionotropic glutamate receptor binding	molecular function	IBA	8
GO:0008285	negative regulation of cell proliferation	biological process	NAS[9188857]	41
GO:0005923	tight junction	cellular component	IEA	13
GO:0046939	nucleotide phosphorylation	biological process	IBA	3
GO:0019903	protein phosphatase binding	molecular function	IEA	5
GO:0005515	protein binding	molecular function	IPI[19118189]	563
GO:0014069	postsynaptic density	cellular component	IBA	26
GO:0016323	basolateral plasma membrane	cellular component	IBA	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 27)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DLG3	LRP2	NO	in vitro;yeast 2-hybrid	12713445
DLG3	CRIPT	NO	in vitro;in vivo;yeast 2-hybrid	11937501 , 12070168
DLG3	KCNJ2	NO	in vitro	16637659
DLG3	KCNJ12	NO	in vitro;in vivo	15024025
DLG3	NLGN3	NO	yeast 2-hybrid	9278515
DLG3	LIN7A	NO	in vitro	9753324
DLG3	CALM1	NO	in vitro;in vivo;yeast 2-hybrid	10026200
DLG3	ATP2B4	NO	in vitro;in vivo;yeast 2-hybrid	11274188
DLG3	GRIN2B	YES	in vitro;in vivo	11937501 , 8780649
DLG3	GLS2	NO	in vitro	16637659
DLG3	SEMA4C	NO	in vitro;yeast 2-hybrid	11134026
DLG3	DLGAP4	NO	yeast 2-hybrid	9115257
DLG3	KIF1B	NO	in vitro	16637659
DLG3	PTK2B	YES	in vitro;in vivo	12576483
DLG3	LPHN1	NO	yeast 2-hybrid	10958799
DLG3	GUCY1A2	NO	in vitro	11572861
DLG3	MAPK12	NO	in vitro	16637659
DLG3	GRIN1	YES	in vivo	10862698
DLG3	SCN5A	NO	in vitro	16637659
DLG3	DLGAP3	NO	yeast 2-hybrid	9115257
DLG3	GRIN2C	YES	in vitro;in vivo	11937501
DLG3	GDA	YES	in vitro;in vivo;yeast 2-hybrid	10542258 , 10595517
DLG3	KCNA4	NO	in vitro	16637659
DLG3	CNKSR2	NO	in vitro	16637659
DLG3	DLG4	NO	in vitro;in vivo;yeast 2-hybrid	10026200
DLG3	ABCA1	YES	in vitro	16192271
DLG3	SCN4A	NO	in vitro	16637659

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chrX:70444861..70505490 View in gBrowse