Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	DLG3
Symbol Alias	NE-Dlg, SAP102, SAP-102, NEDLG, KIAA1232, MRX90, PPP1R82
Approved Name	discs, large homolog 3 (Drosophila)
Previous Name	discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
Name Alias	neuroendocrine-dlg, "protein phosphatase 1, regulatory subunit 82"
Location	Xq13.1
Position	chrX:70444861-70505490, 1
External Links	HGNC: 2902 Entrez Gene: 1741 Ensembl: ENSG00000082458 UCSC: uc004dyi.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Xu, W., 2014		SNPs were identified with suggestive association at a number of other genes with plausible biological arguments for involvement in, and/or previous associations to BD, such as the synapseassociated protein 102 gene, DLG3 (p = 5.31Ã—10-5).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 30)

GO terms by PBA (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030165	PDZ domain binding	molecular function	IEA	16
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0007399	nervous system development	biological process	IBA	40
GO:0045211	postsynaptic membrane	cellular component	IBA	68
GO:0007268	synaptic transmission	biological process	IBA; TAS	116
GO:0007411	axon guidance	biological process	TAS	60

GO terms by database search (count: 24)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity	biological process	IBA	3
GO:0043198	dendritic shaft	cellular component	IEA	7
GO:0005615	extracellular space	cellular component	IDA[22664934]	85
GO:0019902	phosphatase binding	molecular function	IDA[19389623]	9
GO:0008328	ionotropic glutamate receptor complex	cellular component	IBA	6
GO:0004385	guanylate kinase activity	molecular function	IBA	3
GO:0001736	establishment of planar polarity	biological process	IEA	3
GO:0032281	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex	cellular component	IEA	8
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0097120	receptor localization to synapse	biological process	IBA	5
GO:0030426	growth cone	cellular component	IEA	22
GO:0043113	receptor clustering	biological process	IBA	8
GO:0008022	protein C-terminus binding	molecular function	IEA	21
GO:0031625	ubiquitin protein ligase binding	molecular function	IEA	25
GO:0010923	negative regulation of phosphatase activity	biological process	IDA[19389623]	5
GO:0035255	ionotropic glutamate receptor binding	molecular function	IBA	8
GO:0008285	negative regulation of cell proliferation	biological process	NAS[9188857]	41
GO:0005923	tight junction	cellular component	IEA	13
GO:0046939	nucleotide phosphorylation	biological process	IBA	3
GO:0019903	protein phosphatase binding	molecular function	IEA	5
GO:0005515	protein binding	molecular function	IPI[19118189]	563
GO:0014069	postsynaptic density	cellular component	IBA	26
GO:0016323	basolateral plasma membrane	cellular component	IBA	21

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 27)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DLG3	GRIN2C	YES	in vitro;in vivo	11937501
DLG3	CALM1	NO	in vitro;in vivo;yeast 2-hybrid	10026200
DLG3	MAPK12	NO	in vitro	16637659
DLG3	CRIPT	NO	in vitro;in vivo;yeast 2-hybrid	11937501 , 12070168
DLG3	KCNA4	NO	in vitro	16637659
DLG3	DLGAP4	NO	yeast 2-hybrid	9115257
DLG3	KIF1B	NO	in vitro	16637659
DLG3	SCN5A	NO	in vitro	16637659
DLG3	SEMA4C	NO	in vitro;yeast 2-hybrid	11134026
DLG3	GRIN1	YES	in vivo	10862698
DLG3	GUCY1A2	NO	in vitro	11572861
DLG3	GRIN2B	YES	in vitro;in vivo	11937501 , 8780649
DLG3	ABCA1	YES	in vitro	16192271
DLG3	DLG4	NO	in vitro;in vivo;yeast 2-hybrid	10026200
DLG3	ATP2B4	NO	in vitro;in vivo;yeast 2-hybrid	11274188
DLG3	LPHN1	NO	yeast 2-hybrid	10958799
DLG3	DLGAP3	NO	yeast 2-hybrid	9115257
DLG3	PTK2B	YES	in vitro;in vivo	12576483
DLG3	KCNJ2	NO	in vitro	16637659
DLG3	NLGN3	NO	yeast 2-hybrid	9278515
DLG3	GDA	YES	in vitro;in vivo;yeast 2-hybrid	10542258 , 10595517
DLG3	SCN4A	NO	in vitro	16637659
DLG3	CNKSR2	NO	in vitro	16637659
DLG3	GLS2	NO	in vitro	16637659
DLG3	KCNJ12	NO	in vitro;in vivo	15024025
DLG3	LRP2	NO	in vitro;yeast 2-hybrid	12713445
DLG3	LIN7A	NO	in vitro	9753324

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chrX:70444861..70505490 View in gBrowse