Gene Report

Approved Symbol	PIP4K2A
Previous Symbol	PIP5K2A
Symbol Alias	PIP5KIIA, PIP5KIIalpha
Approved Name	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Previous Name	phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
Location	10p12.2
Position	chr10:22534849-22714555, -1
External Links	HGNC: 8997 Entrez Gene: 5305 Ensembl: ENSG00000150867 UCSC: uc001irl.4
No. of Studies	4 (Positive: 1; Negative: 3; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Jamra, R. A., 2006 (a)	SNP: rs1053454, rs1417374, rs1539628, rs943194, rs997650	Our results do not suggest that a common genetic variant at the PIP5K2A locus contributes to the development of schizophrenia and/or BPAD in patients of German descent.	Negative	Comment on Study
Stopkova, P.,2003	Other variant: PIP5K2A_Exon7_N251S, PIP5K2A_Exon10_1257T->G, PIP5K2A_Exon10_1412G->C, PIP5K2A_Exon8_IVS8+20C->G, PIP5K2A_Exon10_Codon 391(GAA->GAG), PIP5K2A_Exon5_Codon 199(GTA->GTG), PIP5K2A_Exon8_Codon 309(CCG->CCA), PIP5K2A_Exon9_Intron 9_CT repeat	Significant associations of PIP5K2A Exon9 Intron 9 CT repeat were found in BPD patients.	Positive	Comment on Study
Stopkova, P.,2005	Other variant: PIP5K2A_-1007C>T	No significant associations were detected in BD patients.	Negative	Comment on Study
Yosifova, A.,2009	SNP: rs1053454, rs2230469	No SNP of this gene had significant association with BD in our population.	Negative	Comment on Study

Region: chr10:22534849..22714555 View in gBrowse