Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	CXCL12
Previous Symbol	SDF1A, SDF1B, SDF1
Symbol Alias	SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1
Approved Name	chemokine (C-X-C motif) ligand 12
Previous Name	stromal cell-derived factor 1
Location	10q11.1
Position	chr10:44370165-44386493, -1
External Links	HGNC: 10672 Entrez Gene: 6387 Ensembl: ENSG00000107562 UCSC: uc021ppm.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs1585913	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 47)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	TAS[10358157]	37
GO:0007155	cell adhesion	biological process	TAS[10198043]	42
GO:0009615	response to virus	biological process	TAS[10772939]	5

GO terms by database search (count: 44)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008344	adult locomotory behavior	biological process	IEA	15
GO:0022029	telencephalon cell migration	biological process	IEA	2
GO:0060326	cell chemotaxis	biological process	IDA[18308860]	4
GO:0008015	blood circulation	biological process	TAS[10772939]	6
GO:0001764	neuron migration	biological process	IEA	18
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	biological process	IDA[20388803]	2
GO:0042379	chemokine receptor binding	molecular function	IMP[22457824]	1
GO:2000406	positive regulation of T cell migration	biological process	IDA[23620790]	1
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0001569	patterning of blood vessels	biological process	IEA	3
GO:1901741	positive regulation of myoblast fusion	biological process	IEA	1
GO:0009314	response to radiation	biological process	IEA	4
GO:0045785	positive regulation of cell adhesion	biological process	IDA[23620790]	4
GO:0090026	positive regulation of monocyte chemotaxis	biological process	IDA[18802065]	2
GO:0050930	induction of positive chemotaxis	biological process	IEA	1
GO:0031100	organ regeneration	biological process	IEA	5
GO:0008354	germ cell migration	biological process	IEA	1
GO:0043434	response to peptide hormone	biological process	IEA	9
GO:0008045	motor neuron axon guidance	biological process	IEA	3
GO:1903237	negative regulation of leukocyte tethering or rolling	biological process	IDA[18308860]	1
GO:0042098	T cell proliferation	biological process	IEA	5
GO:0048842	positive regulation of axon extension involved in axon guidance	biological process	IEA	3
GO:0005576	extracellular region	cellular component	TAS	97
GO:0008064	regulation of actin polymerization or depolymerization	biological process	TAS[10570282]	2
GO:0045236	CXCR chemokine receptor binding	molecular function	IDA[20388803]	1
GO:0008083	growth factor activity	molecular function	IEA	15
GO:0001667	ameboidal-type cell migration	biological process	IEA	1
GO:2000107	negative regulation of leukocyte apoptotic process	biological process	IDA[15059845]	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8752280]	64
GO:0090280	positive regulation of calcium ion import	biological process	TAS[10925302]	3
GO:0008009	chemokine activity	molecular function	IDA[18308860]; TAS[12782716]	2
GO:0009612	response to mechanical stimulus	biological process	IEA	7
GO:0006955	immune response	biological process	IEA	19
GO:0006935	chemotaxis	biological process	TAS[12782716]	7
GO:0009408	response to heat	biological process	IEA	12
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0009897	external side of plasma membrane	cellular component	IEA	21
GO:0007165	signal transduction	biological process	TAS[10491003]	136
GO:0001938	positive regulation of endothelial cell proliferation	biological process	IEA	11
GO:0033603	positive regulation of dopamine secretion	biological process	IEA	4
GO:0070098	chemokine-mediated signaling pathway	biological process	IDA[20388803]	3
GO:0006874	cellular calcium ion homeostasis	biological process	TAS[10772939]	16
GO:0007281	germ cell development	biological process	IEA	5
GO:0005615	extracellular space	cellular component	IEA	85

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa04670	Leukocyte transendothelial migration	13
hsa04360	Axon guidance	16
hsa04060	Cytokine-cytokine receptor interaction	17

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
cxcr4Pathway	CXCR4 Signaling Pathway	3
Ccr5Pathway	Pertussis toxin-insensitive CCR5 Signaling in Macrophage	3

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CXCL12	CXCR4	NO	in vitro;in vivo	10233851 , 8752281
CXCL12	MMP2	YES	in vitro	11571304
CXCL12	ELANE	NO	in vitro	12068293
CXCL12	DPP4	NO	in vitro	11390394
CXCL12	CTSG	NO	in vitro;in vivo	11241273
CXCL12	FN1	NO	in vivo	11023498
CXCL12	CD4	NO	in vitro	10600606

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1585913	chr10:44622528 - 44622528(1)		1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11.21-q22.1	chr10:34200000-73100000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q11.21-q22.1	chr10:41600000-73100000	1 (0/0/1)
10q11-q21	chr10:39800000-68800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:44370165..44386493 View in gBrowse