Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

ADD to My Gene Set

Comment on Gene

View All Comments on Gene

Basic Info

Approved Symbol	CXCL12
Previous Symbol	SDF1A, SDF1B, SDF1
Symbol Alias	SCYB12, SDF-1a, SDF-1b, PBSF, TLSF-a, TLSF-b, TPAR1
Approved Name	chemokine (C-X-C motif) ligand 12
Previous Name	stromal cell-derived factor 1
Location	10q11.1
Position	chr10:44370165-44386493, -1
External Links	HGNC: 10672 Entrez Gene: 6387 Ensembl: ENSG00000107562 UCSC: uc021ppm.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Smith, E. N.,2011	SNP: rs1585913	Suggestive association of this gene was found.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 47)

GO terms by PBA (count: 3)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	TAS[10358157]	37
GO:0007155	cell adhesion	biological process	TAS[10198043]	42
GO:0009615	response to virus	biological process	TAS[10772939]	5

GO terms by database search (count: 44)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008344	adult locomotory behavior	biological process	IEA	15
GO:0022029	telencephalon cell migration	biological process	IEA	2
GO:0060326	cell chemotaxis	biological process	IDA[18308860]	4
GO:0008015	blood circulation	biological process	TAS[10772939]	6
GO:0001764	neuron migration	biological process	IEA	18
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	biological process	IDA[20388803]	2
GO:0042379	chemokine receptor binding	molecular function	IMP[22457824]	1
GO:2000406	positive regulation of T cell migration	biological process	IDA[23620790]	1
GO:0001666	response to hypoxia	biological process	IEA	24
GO:0001569	patterning of blood vessels	biological process	IEA	3
GO:1901741	positive regulation of myoblast fusion	biological process	IEA	1
GO:0009314	response to radiation	biological process	IEA	4
GO:0045785	positive regulation of cell adhesion	biological process	IDA[23620790]	4
GO:0090026	positive regulation of monocyte chemotaxis	biological process	IDA[18802065]	2
GO:0050930	induction of positive chemotaxis	biological process	IEA	1
GO:0031100	organ regeneration	biological process	IEA	5
GO:0008354	germ cell migration	biological process	IEA	1
GO:0043434	response to peptide hormone	biological process	IEA	9
GO:0008045	motor neuron axon guidance	biological process	IEA	3
GO:1903237	negative regulation of leukocyte tethering or rolling	biological process	IDA[18308860]	1
GO:0042098	T cell proliferation	biological process	IEA	5
GO:0048842	positive regulation of axon extension involved in axon guidance	biological process	IEA	3
GO:0005576	extracellular region	cellular component	TAS	97
GO:0008064	regulation of actin polymerization or depolymerization	biological process	TAS[10570282]	2
GO:0045236	CXCR chemokine receptor binding	molecular function	IDA[20388803]	1
GO:0008083	growth factor activity	molecular function	IEA	15
GO:0001667	ameboidal-type cell migration	biological process	IEA	1
GO:2000107	negative regulation of leukocyte apoptotic process	biological process	IDA[15059845]	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	TAS[8752280]	64
GO:0090280	positive regulation of calcium ion import	biological process	TAS[10925302]	3
GO:0008009	chemokine activity	molecular function	IDA[18308860]; TAS[12782716]	2
GO:0009612	response to mechanical stimulus	biological process	IEA	7
GO:0006955	immune response	biological process	IEA	19
GO:0006935	chemotaxis	biological process	TAS[12782716]	7
GO:0009408	response to heat	biological process	IEA	12
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23376485]	176
GO:0009897	external side of plasma membrane	cellular component	IEA	21
GO:0007165	signal transduction	biological process	TAS[10491003]	136
GO:0001938	positive regulation of endothelial cell proliferation	biological process	IEA	11
GO:0033603	positive regulation of dopamine secretion	biological process	IEA	4
GO:0070098	chemokine-mediated signaling pathway	biological process	IDA[20388803]	3
GO:0006874	cellular calcium ion homeostasis	biological process	TAS[10772939]	16
GO:0007281	germ cell development	biological process	IEA	5
GO:0005615	extracellular space	cellular component	IEA	85

Gene related KEGG pathways (count: 3)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 3)

ID	Name	No. of Genes in BDgene
hsa04670	Leukocyte transendothelial migration	13
hsa04360	Axon guidance	16
hsa04060	Cytokine-cytokine receptor interaction	17

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
cxcr4Pathway	CXCR4 Signaling Pathway	3
Ccr5Pathway	Pertussis toxin-insensitive CCR5 Signaling in Macrophage	3

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
CXCL12	MMP2	YES	in vitro	11571304
CXCL12	DPP4	NO	in vitro	11390394
CXCL12	CD4	NO	in vitro	10600606
CXCL12	ELANE	NO	in vitro	12068293
CXCL12	FN1	NO	in vivo	11023498
CXCL12	CXCR4	NO	in vitro;in vivo	10233851 , 8752281
CXCL12	CTSG	NO	in vitro;in vivo	11241273

Related other genetic factors

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs1585913	chr10:44622528 - 44622528(1)		1(0/0/1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10p11.21-q22.1	chr10:34200000-73100000	1 (1/0/0)
Chr 10	chr10:0-133797422	3 (0/2/1)
10q11.21-q22.1	chr10:41600000-73100000	1 (0/0/1)
10q11-q21	chr10:39800000-68800000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr10:44370165..44386493 View in gBrowse