Gene Report

Basic Info
Approved Symbol HTR3B
Symbol Alias 5-HT3B
Approved Name 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
Previous Name 5-hydroxytryptamine (serotonin) receptor 3B
Location 11q23.1
Position chr11:113904677-113946565, 1
External Links HGNC: 5298
Entrez Gene: 9177
Ensembl: ENSG00000149305
UCSC: uc001pok.3
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Yosifova, A.,2009 SNP: rs1176744, rs17116138 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Frank, B., 2004 Other variant: HTR3B_386A>C (Tyr129Ser), HTR3B_547G>A (Val183Ile), HTR3B_IVS4+11C>T, HTR3B_IVS4+12G>A, HTR3B_IVS6+72A>G, HTR3B_5'UTR_ -102delAAG we observed a significant underrepresentation of the 3 bp deletion -100_-102delAAG in an extended sample of 162 bipolar affected patients compared to controls (allele-wise: 8% vs. 15%, P = 0.006, OR = 0.49, 95% CI: 0.3-0.82; genotype-wise: 15, 5% vs. 29, 0%, P = 0.005, OR = 0.45, 95% CI: 0.26-0.77). We suggest that this deletion may influence translational efficiency, thereby possibly affecting the development of bipolar affective disease. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 13)

GO terms by PBA (count: 5)

GO terms by database search (count: 8)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors
Gene related SNPs (count: 16)

Literature-origin SNPs (count: 2)

LD-proxies (count: 14)

Gene related CNVs (count: 0)

Gene related other variants (count: 6)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr11:113904677..113946565 View in gBrowse
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