Gene Report

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Basic Info

Approved Symbol	DDO
Approved Name	D-aspartate oxidase
Location	6q22.1
Position	chr6:110391771-110415562, -1
External Links	HGNC: 2727 Entrez Gene: 8528 Ensembl: ENSG00000203797 UCSC: uc003puc.3
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fan, J., 2010	SNP: rs3823447, rs6938431	For gene-based test, P-value = 0.00079 in STEP1; P-value = 0.46 in NIMH; P-value = 0.0033 in STEP1 and NIMH. leading gene-based results, but not survive Bonferroni correction test.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 12)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005102	receptor binding	molecular function	IPI[20178365]	37
GO:0048037	cofactor binding	molecular function	IDA[20603179]	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005777	peroxisome	cellular component	NAS[9820813]	5
GO:0019478	D-amino acid catabolic process	biological process	IDA[20603179]	1
GO:0042445	hormone metabolic process	biological process	IEA	4
GO:0055114	oxidation-reduction process	biological process	IDA[9163533]; IEA	43
GO:0006533	aspartate catabolic process	biological process	IDA[9163533]	1
GO:0007625	grooming behavior	biological process	IEA	5
GO:0005515	protein binding	molecular function	IPI[9820813]	563
GO:0007320	insemination	biological process	IEA	1
GO:0006531	aspartate metabolic process	biological process	IEA	2
GO:0008445	D-aspartate oxidase activity	molecular function	IDA[20603179]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00252	Alanine and aspartate metabolism	5

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
DDO	PEX5	NO	in vitro;in vivo	9820813

Related other genetic factors

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs3823447	chr6:110424616 - 110424616(1)	downstream_gene_variant	1(1/0/0)
rs6938431	chr6:110424403 - 110424403(1)	downstream_gene_variant	1(1/0/0)

rs_ID	Literature-origin SNPs with LD	Location	Functional Annotation
rs2207356		chr6:110420408 - 110420408(1)	downstream_gene_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6q16-q21	chr6:100000000-114200000	1 (0/0/1)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q21	chr6:105000000-114200000	4 (1/2/1)
6q14-22	chr6:75200000-130000000	1 (0/0/1)
6q21-22	chr6:105000000-130000000	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
19125110	772	Negative

Gene relationship with MDD

View in gBrowse

Region: chr6:110391771..110415562 View in gBrowse