Gene Report

Basic Info
Approved Symbol GNAS
Previous Symbol GNAS1
Approved Name GNAS complex locus
Previous Name guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1
Name Alias secretogranin VI
Location 20q13.2-q13.3
Position chr20:58839718-58911192, 1
External Links HGNC: 4392
Entrez Gene: 2778
Ensembl: ENSG00000087460
UCSC: uc002xzt.4
No. of Studies 1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
McDonald, M. L.,2012 SNP: rs35113254, rs6026565, rs6064714 None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08). Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 71)

GO terms by PBA (count: 7)

GO terms by database search (count: 64)

Gene related KEGG pathways (count: 7)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 4)

Gene related BioCarta pathways (count: 13)

Gene related interactors from protein-protein interactions data in HPRD (count: 23)

Related other genetic factors
Gene related SNPs (count: 4)

Literature-origin SNPs (count: 3)

LD-proxies (count: 1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 1)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr20:58839718..58911192 View in gBrowse
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