Gene Report

Basic Info
Approved Symbol IL1B
Symbol Alias IL1F2, IL-1B, IL1-BETA
Approved Name interleukin 1, beta
Location 2q14
Position chr2:112829751-112836903, -1
External Links HGNC: 5992
Entrez Gene: 3553
Ensembl: ENSG00000125538
UCSC: uc002tii.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Papiol, S.,2004 SNP: rs16944
Haplotype: rs16944 - (IL1RN_intron 2_VNTR)(C-VNTR(A2))
IL-1 cluster genetic variability may represent a shared genetic susceptibility factor both for schizophrenia and bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 79)

GO terms by PBA (count: 3)

GO terms by database search (count: 76)

Gene related KEGG pathways (count: 8)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 6)

Gene related BioCarta pathways (count: 4)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 4)

Gene related interactors from protein-protein interactions data in HPRD (count: 8)

Related other genetic factors
Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Gene related regions (count: 3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 1)

Overlap with SZ from candidate gene intersection analysis (count: 13)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 4)

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Region: chr2:112829751..112836903 View in gBrowse
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