Gene Report

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Basic Info

Approved Symbol	ANO2
Previous Symbol	C12orf3, TMEM16B
Approved Name	anoctamin 2, calcium activated chloride channel
Previous Name	chromosome 12 open reading frame 3, "transmembrane protein 16B", "anoctamin 2"
Name Alias	transmembrane protein 16B (eight membrane-spanning domains)
Location	12p13.3
Position	chr12:5531869-5946232, -1
External Links	HGNC: 1183 Entrez Gene: 57101 Ensembl: ENSG00000047617 UCSC: uc031yre.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs4140862	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	IDA; ISS; TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042803	protein homodimerization activity	molecular function	IEA	71
GO:1902476	chloride transmembrane transport	biological process	IDA[19474308]; IEA	16
GO:0031513	nonmotile primary cilium	cellular component	IEA	2
GO:0034707	chloride channel complex	cellular component	IEA	13
GO:0055085	transmembrane transport	biological process	TAS	77
GO:0046982	protein heterodimerization activity	molecular function	IEA	42
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005229	intracellular calcium activated chloride channel activity	molecular function	IDA[19474308]	3
GO:0034220	ion transmembrane transport	biological process	TAS	50

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4140862	chr12:5595718 - 5595718(1)	intron_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 12	chr12:0-133275309	3 (0/3/0)
12p13	chr12:0-14600000	1 (0/1/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr12:5531869..5946232 View in gBrowse