Gene Report

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Basic Info

Approved Symbol	SLK
Symbol Alias	STK2, se20-9, KIAA0204
Approved Name	STE20-like kinase
Previous Name	SNF1 (sucrose nonfermenting, yeast, homolog)-like kinase, SNF1 sucrose nonfermenting like kinase (yeast), "STE20-like kinase (yeast)"
Location	10q25.1
Position	chr10:103967201-104029233, 1
External Links	HGNC: 11088 Entrez Gene: 9748 Ensembl: ENSG00000065613 UCSC: uc001kxo.1
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cruceanu, C., 2013	Other variant: SLK_Chr10:105779646_C/T	Rare variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0004674	protein serine/threonine kinase activity	molecular function	IDA[18239682]	27

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0042803	protein homodimerization activity	molecular function	IDA[18239682]	71
GO:0046777	protein autophosphorylation	biological process	IDA[18239682]	16
GO:0005737	cytoplasm	cellular component	IBA	322
GO:0042802	identical protein binding	molecular function	IPI[18239682]	44
GO:0005524	ATP binding	molecular function	IEA	118
GO:0004702	receptor signaling protein serine/threonine kinase activity	molecular function	IBA	5
GO:0023014	signal transduction by phosphorylation	biological process	IBA	5
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0006915	apoptotic process	biological process	IEA	39
GO:0035556	intracellular signal transduction	biological process	IBA	38

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SLK	CASP3	NO	in vitro;in vivo	10611247
SLK	CLSTN1	NO	yeast 2-hybrid	12421765

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
SLK_Chr10:105779646_C/T	Missense	Chr10:105779646	1 (0/0/1)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:103967201..104029233 View in gBrowse