Gene Report

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Basic Info

Approved Symbol	HCAR2
Previous Symbol	GPR109A
Symbol Alias	HCA2, HM74A, PUMAG, Puma-g, NIACR1
Approved Name	hydroxycarboxylic acid receptor 2
Previous Name	G protein-coupled receptor 109A
Name Alias	niacin receptor 1
Location	12q24.31
Position	chr12:122701293-122703343, -1
External Links	HGNC: 24827 Entrez Gene: 338442 Ensembl: ENSG00000182782 UCSC: uc001ucx.1
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Shink, E.,2005(a)	Other variant: HM74a_GC09E01A, HM74a_GC09E01B	We found no polymorphisms associated with bipolar disorder in this gene.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IDA[17932499]; TAS	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0001781	neutrophil apoptotic process	biological process	IDA[17932499]	3
GO:0070165	positive regulation of adiponectin secretion	biological process	ISS	1
GO:0050995	negative regulation of lipid catabolic process	biological process	ISS	6
GO:0033031	positive regulation of neutrophil apoptotic process	biological process	IDA[17932499]	2
GO:0070553	nicotinic acid receptor activity	molecular function	ISS	1
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IEA	64

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 2)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
HM74a_GC09E01B	point mutation		1 (0/1/0)
HM74a_GC09E01A	point mutation		1 (0/1/0)

Gene related regions (count: 6)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
12q24.3	chr12:120300000-133275309	1 (1/0/0)
Chr 12	chr12:0-133275309	3 (0/3/0)
12q24	chr12:108600000-133275309	4 (1/1/2)
12q23-q24	chr12:95800000-133275309	3 (2/0/1)
12q24.31	chr12:120300000-125400000	1 (1/0/0)
12q	chr12:38200000-133851895	1 (1/0/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	ID in SZGene	Result Category
19502010	837	Negative

Gene relationship with MDD

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Region: chr12:122701293..122703343 View in gBrowse