Gene Report

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Basic Info

Approved Symbol	ACTR3B
Symbol Alias	ARP11, ARP3beta
Approved Name	ARP3 actin-related protein 3 homolog B (yeast)
Location	7q36.1
Position	chr7:152759749-152855378, 1
External Links	HGNC: 17256 Entrez Gene: 57180 Ensembl: ENSG00000133627 UCSC: uc003wle.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs4726220	Suggestive association was found in BD-II.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003779	actin binding	molecular function	IEA	24

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0008150	biological_process	biological process	ND	24
GO:0034314	Arp2/3 complex-mediated actin nucleation	biological process	IEA	1
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0003674	molecular_function	molecular function	ND	24
GO:0070062	extracellular vesicular exosome	cellular component	IDA[23533145]	176
GO:0005524	ATP binding	molecular function	IEA	118
GO:0042995	cell projection	cellular component	IEA	9
GO:0005885	Arp2/3 protein complex	cellular component	IEA	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 1)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
ACTR3B	RSRC1	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4726220	chr7:152889438 - 152889438(1)		1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 3)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 7	chr7:0-159345973	3 (0/3/0)
7q34-qter	chr7:138500000-159345973	1 (0/1/0)
7q36	chr7:148200000-159345973	3 (0/0/3)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr7:152759749..152855378 View in gBrowse