Gene Report

Basic Info
Approved Symbol TCF7L2
Previous Symbol TCF4
Symbol Alias TCF-4
Approved Name transcription factor 7-like 2 (T-cell specific, HMG-box)
Location 10q25.3
Position chr10:112950250-113167678, 1
External Links HGNC: 11641
Entrez Gene: 6934
Ensembl: ENSG00000148737
UCSC: uc001lae.4
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? NO
Overlap with MDD? NO
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Cuellar-Barboza, A. B., 2016 SNP: rs6585194, rs6585195, rs11196175, rs7924080, rs11196201, rs11196203, rs12255372, rs7087006, rs3750804, rs12184389, rs11196224, rs7085532, rs11196229, rs290475, rs6585209, rs1362943, rs7919185, rs290487, rs1885510, rs7917983, rs7895307, rs4132670, rs3750805, rs12772424, rs10787476, rs290484
Haplotype: rs7895307 - rs12772424(G-T)
P(BMI-unadj)-value=0.57; P(BMI-adj)-value=0.56; P(TCF7L2-BMI interaction)-value=0.042. Gene-level results were consistent with the single SNP results, showing no evidence of a marginal effect of TCF7L2, with (p = 0.56) or without (p = 0.57) BMI adjustment, but a significant TCF7L2-BMI interaction effect (p = 0.042). Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 81)

GO terms by PBA (count: 4)

GO terms by database search (count: 77)

Gene related KEGG pathways (count: 9)

KEGG pathways by PBA (count: 2)

KEGG pathways by database search (count: 7)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 7)

Related other genetic factors
Gene related SNPs (count: 103)

Literature-origin SNPs (count: 28)

LD-proxies (count: 75)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

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Region: chr10:112950250..113167678 View in gBrowse
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