Gene Report

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Basic Info

Approved Symbol	HCRTR2
Symbol Alias	OX2R
Approved Name	hypocretin (orexin) receptor 2
Location	6p12.1
Position	chr6:55106460-55282620, 1
External Links	HGNC: 4849 Entrez Gene: 3062 Ensembl: ENSG00000137252 UCSC: uc032wym.1
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Cho, C. H., 2015		HCRTR2 is located in 6p12 and encodes a G protein-coupled receptor involved in regulation of feeding and sleep behavior.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 14)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	TAS[9491897]	116
GO:0008188	neuropeptide receptor activity	molecular function	TAS[9491897]	5
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0005887	integral component of plasma membrane	cellular component	TAS[9491897]	158

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:1901652	response to peptide	biological process	IBA	5
GO:0007218	neuropeptide signaling pathway	biological process	IEA	18
GO:0042277	peptide binding	molecular function	IBA	11
GO:0022410	circadian sleep/wake cycle process	biological process	IEA	1
GO:0045187	regulation of circadian sleep/wake cycle, sleep	biological process	IBA	4
GO:0017046	peptide hormone binding	molecular function	IEA	4
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	biological process	IEA	11
GO:0007631	feeding behavior	biological process	IEA	12
GO:0032870	cellular response to hormone stimulus	biological process	IBA	9
GO:0016499	orexin receptor activity	molecular function	IBA	2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	92

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
HCRTR2	CD200	NO	in vivo	10981966
HCRTR2	HCRT	NO	in vivo	9491897

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
6p12-q13	chr6:46200000-75200000	1 (0/1/0)
Chr 6	chr6:0-170805979	3 (0/3/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:55106460..55282620 View in gBrowse