Gene Report

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Basic Info

Approved Symbol	FAM20B
Symbol Alias	KIAA0475, GXK1
Approved Name	family with sequence similarity 20, member B
Name Alias	glycosaminoglycan xylosylkinase
Location	1q25.2
Position	chr1:179025804-179076562, 1
External Links	HGNC: 23017 Entrez Gene: 9917 Ensembl: ENSG00000116199 UCSC: uc001gmc.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs4271171	No significant association of this gene was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 9)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016310	phosphorylation	biological process	IEA	9
GO:0005524	ATP binding	molecular function	IEA	118
GO:0000139	Golgi membrane	cellular component	IEA	36
GO:0016301	kinase activity	molecular function	IEA	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	molecular function	IDA[19473117]	2
GO:0005654	nucleoplasm	cellular component	IDA	163
GO:0005794	Golgi apparatus	cellular component	IDA	60
GO:1903955	positive regulation of protein targeting to mitochondrion	biological process	IMP[24270810]	7

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs4271171	chr1:179016523 - 179016523(1)		1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p32.1-q31.1	chr1:58500000-190800000	1 (0/1/0)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr1:179025804..179076562 View in gBrowse