Gene Report

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Basic Info

Approved Symbol	PDE10A
Approved Name	phosphodiesterase 10A
Location	6q26
Position	chr6:165327287-165986603, -1
External Links	HGNC: 8772 Entrez Gene: 10846 Ensembl: ENSG00000112541 UCSC: uc003quo.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
McDonald, M. L.,2012	SNP: rs10214709, rs1033701, rs1079418, rs2983517, rs2983521, rs3008049, rs4709082, rs470922, rs9365899, rs9459417, rs9459464, rs9459465	None of the association tests of the tagSNPs with either BPD I or BPD II reached genome-wide significance (P < 5E-08).	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030553	cGMP binding	molecular function	NAS[15938621]	1
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	molecular function	TAS[10373451]	3

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0030552	cAMP binding	molecular function	IDA[19689430]; NAS[15938621]	5
GO:0007165	signal transduction	biological process	IEA	136
GO:0046069	cGMP catabolic process	biological process	IEA	1
GO:0007596	blood coagulation	biological process	TAS	44
GO:0010738	regulation of protein kinase A signaling	biological process	IEA	3
GO:0004118	cGMP-stimulated cyclic-nucleotide phosphodiesterase activity	molecular function	IDA[19689430]	1
GO:0046872	metal ion binding	molecular function	IEA	115
GO:0005829	cytosol	cellular component	TAS	223
GO:0043949	regulation of cAMP-mediated signaling	biological process	IEA	1
GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity	molecular function	IEA	1
GO:0006198	cAMP catabolic process	biological process	IEA	3

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa00230	Purine metabolism	12

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
PDE10A	CASP3	NO	in vitro	11602184
PDE10A	WDR3	NO	yeast 2-hybrid	16169070

Related other genetic factors

Gene related SNPs (count: 23)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs2983521	chr6:165643715 - 165643715(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9365899	chr6:165648891 - 165648891(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9459464	chr6:165629217 - 165629217(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs1033701	chr6:165627371 - 165627371(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs1079418	chr6:165633546 - 165633546(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs4709082	chr6:165627133 - 165627133(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9459465	chr6:165635380 - 165635380(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs3008049	chr6:165650129 - 165650129(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs9459417	chr6:165424504 - 165424504(1)	intron_variant	1(0/1/0)
rs10214709	chr6:165653405 - 165653405(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs2983517	chr6:165638243 - 165638243(1)	intron_variant; non_coding_transcript_variant	1(0/1/0)
rs470922	chr6:165430823 - 165430823(1)	intron_variant	1(0/1/0)

rs_ID	Location	Functional Annotation
rs2983516	chr6:165638020 - 165638020(1)	intron_variant; non_coding_transcript_variant
rs2983514	chr6:165636631 - 165636631(1)	intron_variant; non_coding_transcript_variant
rs2983525	chr6:165647113 - 165647113(1)	intron_variant; non_coding_transcript_variant
rs3008043	chr6:165639144 - 165639144(1)	intron_variant; non_coding_transcript_variant
rs9348023	chr6:165626892 - 165626892(1)	intron_variant; non_coding_transcript_variant
rs4709081	chr6:165626987 - 165626987(1)	intron_variant; non_coding_transcript_variant
rs2983511	chr6:165630471 - 165630471(1)	intron_variant; non_coding_transcript_variant
rs753760	chr6:165632995 - 165632995(1)	intron_variant; non_coding_transcript_variant
rs3008034	chr6:165630374 - 165630374(1)	intron_variant; non_coding_transcript_variant
rs12211836	chr6:165427123 - 165427123(1)	intron_variant
rs11755331	chr6:165638380 - 165638380(1)	intron_variant; non_coding_transcript_variant

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q27	chr6:164100000-170805979	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

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Region: chr6:165327287..165986603 View in gBrowse