Gene Report

Basic Info
Approved Symbol RGS4
Previous Symbol SCZD9
Approved Name regulator of G-protein signaling 4
Previous Name regulator of G-protein signalling 4, "schizophrenia disorder 9"
Location 1q23.3
Position chr1:163068775-163076802, 1
External Links HGNC: 10000
Entrez Gene: 5999
Ensembl: ENSG00000117152
UCSC: uc001gcl.4
No. of Studies 6 (Positive: 3; Negative: 2; trend: 1)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 6)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Cordeiro, Q.,2005 Haplotype: RGS4_SNP1 - RGS4_SNP4 - RGS4_SNP17 - RGS4_SNP18(G-G-G-G)
Other variant: RGS4_SNP1, RGS4_SNP18, RGS4_SNP4, RGS4_SNP7
In conclusion, association analyses using cases and community-based controls from Brazil did not support a putative association between RGS4 and SCZ, though separate analyses using family-based controls provided suggestive evidence. Parallel investigations using BD probands also provided suggestive evidence for an association between RGS4 polymorphisms and BD. Positive Comment on Study
Chowdari, K. V.,2002 Haplotype: (RGS4_SNP1) - (RGS4_SNP4) - (RGS4_SNP7) - (RGS4_SNP18)() P-value < 0.0002 for estimated haplotype frequencies and significant association was found in BD-I. Positive Comment on Study
Prata, D. P., 2006 SNP: rs2661319, rs951436, rs951439
Other variant: RGS4_SNP1
Our work does not support an involvement of RGS4, PRODH, COMTand GRK3 genes in the aetiology of bipolar affective disorder 1 in the Scottish population. Negative Comment on Study
Jamain, S., 2014 SNP: rs12031354 It showed nominal evidence for association with BD. Trend Comment on Study
Fallin, M. D.,2005 3 SNP typed, Median D'=1, Median r<sup>2</sup> =0.36, 1 LD blocks, 0.95 block coverage, there exists SNP or haplotype nominal P-value < 0.01 in SZ and all SNP or haplotype P-value > 0.05 in BP.. This gene is not suggestive to BP. Negative Comment on Study
Li, Y.,2010 SNP: rs266131, rs2842030, rs951436, rs951439
Haplotype: rs951436 - rs951439 - rs266131 - rs2842030(G-G-A-G), rs951436 - rs951439 - rs266131 - rs2842030(G-G-A-T), rs951436 - rs951439 - rs266131 - rs2842030(G-G-G-T), rs951436 - rs951439 - rs266131 - rs2842030(T-A-A-G), rs951436 - rs951439 - rs266131 - rs2842030(T-G-A-T)
Our results provide further evidence to support RGS4 as a potential susceptible gene for bipolar disorder. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 12)

GO terms by PBA (count: 3)

GO terms by database search (count: 9)

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 10)

Related other genetic factors
Gene related SNPs (count: 11)

Literature-origin SNPs (count: 6)

LD-proxies (count: 5)

Gene related CNVs (count: 0)

Gene related other variants (count: 4)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 3)

Overlap with SZ from candidate gene intersection analysis (count: 22)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr1:163068775..163076802 View in gBrowse
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