Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	FLVCR2
Previous Symbol	C14orf58
Symbol Alias	FLJ20371, MFSD7C
Approved Name	feline leukemia virus subgroup C cellular receptor family, member 2
Previous Name	chromosome 14 open reading frame 58, "feline leukemia virus subgroup C cellular receptor 2"
Location	14q24.3
Position	chr14:75578617-75663214, 1
External Links	HGNC: 20105 Entrez Gene: 55640 Ensembl: ENSG00000119686 UCSC: uc001xrs.2
No. of Studies	1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Moskvina, V.,2009		In BP:Smallest P-value per gene=0.00053, Product of P truncation <=0.01=0.00001, Product of P truncation <=0.001=0.00035. It showed evidence for association with BD.	Positive	Comment on Study

Gene functional annotation

Gene related GO terms (count: 6)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0016021	integral component of membrane	cellular component	IEA	219
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0020037	heme binding	molecular function	IDA[20823265]	6
GO:0015232	heme transporter activity	molecular function	IDA[20823265]	1
GO:0055085	transmembrane transport	biological process	IEA	77
GO:0015886	heme transport	biological process	IDA[20823265]	1

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
14q24	chr14:67400000-78800000	1 (0/0/1)
14q24.1-q32.12	chr14:67400000-94200000	1 (0/0/1)
14q22-24	chr14:50400000-78800000	1 (0/0/1)
Chr 14	chr14:0-107043718	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
19065143	It showed no evidence for association with SZ.	Negative

Gene relationship with MDD

View in gBrowse

Region: chr14:75578617..75663214 View in gBrowse