Gene Report

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Basic Info

Approved Symbol	MYO18B
Symbol Alias	BK125H2.1
Approved Name	myosin XVIIIB
Location	22q12.1
Position	chr22:25742144-26031041, 1
External Links	HGNC: 18150 Entrez Gene: 84700 Ensembl: ENSG00000133454 UCSC: uc003abz.1
No. of Studies	2 (Positive: 0; Negative: 2; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	YES

Gene related studies (count: 2)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Huang, J.,2010	SNP: rs1001021	No significant association of this gene was observed in BD.	Negative	Comment on Study
Xu, W., 2014	SNP: rs8140359	The SNP within or near this gene did not achieve genome-wide significance.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003779	actin binding	molecular function	IEA	24
GO:0003774	motor activity	molecular function	IEA	2

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005524	ATP binding	molecular function	IEA	118
GO:0030017	sarcomere	cellular component	IEA	2
GO:0016461	unconventional myosin complex	cellular component	IDA[12547197]	1
GO:0005813	centrosome	cellular component	IDA	34
GO:0008152	metabolic process	biological process	IEA	50
GO:0005654	nucleoplasm	cellular component	IDA	163

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 2)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
MYO18B	PSMC5	NO	in vitro;in vivo;yeast 2-hybrid	16499872
MYO18B	ACTB	NO	in vivo	12547197

Related other genetic factors

Gene related SNPs (count: 2)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs8140359	chr22:25882727 - 25882727(1)	downstream_gene_variant; intron_variant; NMD_transcript_variant; non_coding_transcript_variant	1(0/1/0)
rs1001021	chr22:26007633 - 26007633(1)	intron_variant; NMD_transcript_variant; non_coding_transcript_variant; upstream_gene_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 22	chr22:0-50818468	2 (0/1/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
20713499	No significant association of this gene was observed in SZ.	Negative

Reference	ID in SZGene	Result Category
19571811	864	Positive

Gene relationship with MDD

Reference	Description	Category in MDD
20713499	No significant association was observed in MDD.	Negative

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Region: chr22:25742144..26031041 View in gBrowse