Gene Report

Basic Info
Approved Symbol GABRB2
Approved Name gamma-aminobutyric acid (GABA) A receptor, beta 2
Name Alias GABA(A) receptor, beta 2
Location 5q34
Position chr5:161288429-161549044, -1
External Links HGNC: 4082
Entrez Gene: 2561
Ensembl: ENSG00000145864
UCSC: uc003lys.1
No. of Studies 1 (Positive: 1; Negative: 0; trend: 0)
Overlap with SZ? YES
Overlap with MDD? YES
Gene related studies (count: 1)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Perlis, 2008 SNP: rs10515827, rs1644454, rs194073, rs3850733, rs967771 permuted P< .005 in gene-based association tests. No genes specifically chosen to probe the action of lithium were associated with bipolar disorder. However, gene-based analysis of sialyltransferase 4A (SIAT4A), tachykinin receptor 1 (TACR1), and -aminobutyric acidA 2 receptor subunit (GABRB2) yielded evidence of association. Positive Comment on Study
Gene functional annotation
Gene related GO terms (count: 24)

GO terms by PBA (count: 6)

GO terms by database search (count: 18)

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 4)

Related other genetic factors
Gene related SNPs (count: 44)

Literature-origin SNPs (count: 7)

LD-proxies (count: 37)

Gene related CNVs (count: 1)

Gene related other variants (count: 0)

Gene related regions (count: 2)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 12)

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 2)

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Region: chr5:161288429..161549044 View in gBrowse
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