Gene Report

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Basic Info

Approved Symbol	SNCG
Symbol Alias	BCSG1, SR, persyn
Approved Name	synuclein, gamma (breast cancer-specific protein 1)
Name Alias	synoretin
Location	10q23.2-q23.3
Position	chr10:86958618-86963260, 1
External Links	HGNC: 11141 Entrez Gene: 6623 Ensembl: ENSG00000173267 UCSC: uc001keb.2
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Fallin, M. D.,2005		5 SNP typed, Median D'=0.11, Median r<sup>2</sup> =0.01, 4 LD blocks, 0.01 block coverage, all SNP or haplotype P-value > 0.05 in BP and SZ/SZA.. This gene is not suggestive to BP.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 20)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007268	synaptic transmission	biological process	IEA	116
GO:0005886	plasma membrane	cellular component	IEA	360

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0050808	synapse organization	biological process	IEA	3
GO:0048487	beta-tubulin binding	molecular function	IEA	4
GO:0043014	alpha-tubulin binding	molecular function	IEA	4
GO:0042220	response to cocaine	biological process	IEA	12
GO:0005819	spindle	cellular component	IEA	9
GO:0008344	adult locomotory behavior	biological process	IEA	15
GO:0070062	extracellular vesicular exosome	cellular component	IDA[19056867]	176
GO:0005815	microtubule organizing center	cellular component	IEA	10
GO:0043025	neuronal cell body	cellular component	IEA	50
GO:0042493	response to drug	biological process	IEA	57
GO:0005737	cytoplasm	cellular component	IDA[17222866]	322
GO:0009306	protein secretion	biological process	IEA	3
GO:0048471	perinuclear region of cytoplasm	cellular component	IEA	50
GO:0014059	regulation of dopamine secretion	biological process	IEA	8
GO:0002118	aggressive behavior	biological process	IEA	4
GO:0071464	cellular response to hydrostatic pressure	biological process	IEA	1
GO:0046928	regulation of neurotransmitter secretion	biological process	IEA	7
GO:0043679	axon terminus	cellular component	IEA	8

Gene related KEGG pathways (count: 0)

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 5)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
SNCG	BUB1B	NO	in vitro;in vivo;yeast 2-hybrid	14576821
SNCG	MAPK8	NO	in vivo	12121974
SNCG	MAPK3	NO	in vivo	12121974
SNCG	GRK5	NO	in vitro	10852916
SNCG	MAPK1	NO	in vivo	12121974

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
10q22.3-23.32	chr10:75900000-92300000	1 (0/1/0)
10q22.1-q24.1	chr10:68800000-97500000	1 (1/0/0)
10q22.3-24.1	chr10:75900000-97500000	1 (0/1/0)
Chr 10	chr10:0-133797422	3 (0/2/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Reference	Description	Result Category
16380905	This gene is not suggestive to SZ/SZA.	Negative

Reference	ID in SZGene	Result Category
16380905	181	Negative

Gene relationship with MDD

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Region: chr10:86958618..86963260 View in gBrowse