Gene Report

ADD to My Gene Set

Basic Info

Approved Symbol	TAS1R3
Symbol Alias	T1R3
Approved Name	taste receptor, type 1, member 3
Location	1p36
Position	chr1:1331314-1335306, 1
External Links	HGNC: 15661 Entrez Gene: 83756 Ensembl: ENSG00000169962 UCSC: uc010nyk.2
No. of Studies	1 (Positive: 0; Negative: 0; trend: 1)
Overlap with SZ?	NO
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Georgi, B., 2014	SNP: rs376489341	Amish-specific putative damaging exonic missense variant was found within this gene.	Trend	Comment on Study

Gene functional annotation

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0005886	plasma membrane	cellular component	TAS	360
GO:0016021	integral component of membrane	cellular component	IC[11917125]	219

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0007186	G-protein coupled receptor signaling pathway	biological process	IC[16720576]	64
GO:0001582	detection of chemical stimulus involved in sensory perception of sweet taste	biological process	IDA[16720576]	1
GO:0033041	sweet taste receptor activity	molecular function	IDA[16720576]	1
GO:0008527	taste receptor activity	molecular function	IDA[11917125]; IDA[16720576]	1
GO:0050916	sensory perception of sweet taste	biological process	IDA[11917125]	1
GO:0046982	protein heterodimerization activity	molecular function	NAS[11917125]	42
GO:0050917	sensory perception of umami taste	biological process	IDA[11917125]	1
GO:1903767	sweet taste receptor complex	cellular component	IDA[16720576]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa04742	Taste transduction	7

Gene related BioCarta pathways (count: 0)

Gene related interactors from protein-protein interactions data in HPRD (count: 0)

Related other genetic factors

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (Positive/Negative/Trend)
rs376489341	chr1:1333691 - 1333691(1)	downstream_gene_variant; missense_variant	1(0/0/1)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 5)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
1p35-p36	chr1:0-34300000	1 (1/0/0)
1p33-p36	chr1:0-50200000	1 (0/0/1)
1p36	chr1:0-27600000	1 (0/1/0)
1p36.33	chr1:0-2300000	1 (0/0/1)
Chr 1	chr1:0-248956422	2 (0/2/0)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Gene relationship with MDD

View in gBrowse

Region: chr1:1331314..1335306 View in gBrowse