Gene Report

Basic information

Related studies

Functional annotation

Related other genetic factors

Overlap with SZ and MDD

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Basic Info

Approved Symbol	TBP
Previous Symbol	GTF2D1, SCA17
Symbol Alias	TFIID
Approved Name	TATA box binding protein
Location	6q27
Position	chr6:170554302-170572870, 1
External Links	HGNC: 11588 Entrez Gene: 6908 Ensembl: ENSG00000112592 UCSC: uc003qxu.3
No. of Studies	1 (Positive: 0; Negative: 1; trend: 0)
Overlap with SZ?	YES
Overlap with MDD?	NO

Gene related studies (count: 1)

Reference	Tested Markers	Statistical Values/Author Comments	Result Category	Comment on Study
Turecki, G.,2000	Other variant: TBP_CAG/CAA repeats	No significant association was observed in BD.	Negative	Comment on Study

Gene functional annotation

Gene related GO terms (count: 29)

GO terms by PBA (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA	66

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in BDgene
GO:0010467	gene expression	biological process	TAS	41
GO:0006360	transcription from RNA polymerase I promoter	biological process	TAS	1
GO:0006361	transcription initiation from RNA polymerase I promoter	biological process	TAS	1
GO:0005719	nuclear euchromatin	cellular component	IDA[19861239]	5
GO:0005737	cytoplasm	cellular component	IEA	322
GO:0016032	viral process	biological process	TAS	26
GO:0006368	transcription elongation from RNA polymerase II promoter	biological process	TAS	2
GO:0006367	transcription initiation from RNA polymerase II promoter	biological process	IC[7729427]; TAS	20
GO:0001939	female pronucleus	cellular component	IEA	1
GO:0019899	enzyme binding	molecular function	IPI[25336585]	34
GO:0006362	transcription elongation from RNA polymerase I promoter	biological process	TAS	1
GO:0040029	regulation of gene expression, epigenetic	biological process	TAS	3
GO:0045814	negative regulation of gene expression, epigenetic	biological process	TAS	3
GO:0008134	transcription factor binding	molecular function	IPI[11005381]	28
GO:0006366	transcription from RNA polymerase II promoter	biological process	IC[7729427]; IDA[7724559]; TAS	31
GO:0005515	protein binding	molecular function	IPI[10391676]	563
GO:0044212	transcription regulatory region DNA binding	molecular function	IDA[16540471]	17
GO:0000183	chromatin silencing at rDNA	biological process	TAS	2
GO:0007283	spermatogenesis	biological process	IEA	29
GO:0005672	transcription factor TFIIA complex	cellular component	IDA[7724559]	1
GO:0005669	transcription factor TFIID complex	cellular component	IDA[14580349]	2
GO:0005654	nucleoplasm	cellular component	IDA; TAS	163
GO:0001103	RNA polymerase II repressing transcription factor binding	molecular function	IEA	2
GO:0006383	transcription from RNA polymerase III promoter	biological process	IDA[9027316]; TAS	2
GO:0006363	termination of RNA polymerase I transcription	biological process	TAS	1
GO:0001940	male pronucleus	cellular component	IEA	1
GO:0070491	repressing transcription factor binding	molecular function	IPI[18838386]	4
GO:0045893	positive regulation of transcription, DNA-templated	biological process	IEA	58

Gene related KEGG pathways (count: 1)

KEGG pathways by PBA (count: 0)

KEGG pathways by database search (count: 1)

ID	Name	No. of Genes in BDgene	Brief Description
hsa03022	Basal transcription factors	1

Gene related BioCarta pathways (count: 2)

BioCarta pathways by PBA (count: 0)

BioCarta pathways by database search (count: 2)

ID	Name	No. of Genes in BDgene	Brief Description
RNApol3Pathway	RNA polymerase III transcription	2
rarrxrPathway	Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells	2

Gene related interactors from protein-protein interactions data in HPRD (count: 76)

Gene	Interactor	Interactor in BDgene?	Experiment Type	PMID
TBP	HTT	YES	in vitro	10410676
TBP	ZNF76	YES	yeast 2-hybrid	16522640
TBP	JUND	NO	in vitro	7848298
TBP	SP1	NO	yeast 2-hybrid	12753906
TBP	DR1	NO	in vitro	11461703
TBP	REL	NO	in vitro	8413269
TBP	BTAF1	NO	in vitro;in vivo	9488487
TBP	TAF7L	NO	in vivo	12665565
TBP	BRF1	NO	in vitro;in vivo;yeast 2-hybrid	7624363 , 10921893 , 16713569
TBP	TRAM2	NO	in vivo	14612417
TBP	FOXF2	NO	in vitro	9722567
TBP	TRIP4	NO	in vitro	10454579
TBP	TAF1	NO	in vitro	7680771
TBP	SNAPC1	NO	in vitro	8524284
TBP	TAF13	NO	in vitro;yeast 2-hybrid	7729427
TBP	POU2F1	NO	in vitro;in vivo	8202368
TBP	CAND2	NO	in vitro	10441524
TBP	JUN	NO	in vitro	7848298 , 16055710
TBP	HSF1	NO	in vitro;in vivo	11005381
TBP	MYC	NO	in vivo	15723054
TBP	RELA	NO	in vitro	9584164 , 7706261
TBP	GTF2A1	NO	in vitro	8006019
TBP	GTF2A2	NO	in vitro;in vivo	7958900 , 9603936 , 7724559
TBP	RUVBL1	NO	in vitro	9843967
TBP	GTF2F2	NO	in vitro	8577725
TBP	GTF2E2	NO	in vitro	9677423 , 11113176
TBP	FOS	NO	in vivo	7685215
TBP	MDM2	NO	in vitro;in vivo	9388200
TBP	GTF2E1	NO	in vitro	11113176
TBP	HNRNPK	NO	in vitro	8628302
TBP	GTF3C3	NO	in vitro;in vivo	10373544
TBP	KDM5A	NO	in vitro	7935440
TBP	TAF1C	NO	in vitro	7801123
TBP	RXRA	NO	in vitro;in vivo;yeast 2-hybrid	7667283
TBP	PAX5	NO	in vitro;in vivo	10197586
TBP	MCM2	NO	in vitro	12392551
TBP	NCOA1	NO	in vitro	8754792
TBP	TP53	NO	in vitro	1465435
TBP	POU2F2	YES	in vitro;in vivo	8202368
TBP	SPIB	NO	in vitro	10196196
TBP	MSX1	NO	in vivo	8700832 , 10215616
TBP	EMID2	NO	yeast 2-hybrid	16713569
TBP	CXXC1	NO	yeast 2-hybrid	16713569
TBP	DHX9	NO	in vivo	11149922
TBP	NFYB	NO	in vitro;in vivo	9153318
TBP	TAF1A	NO	in vitro;in vivo;yeast 2-hybrid	7801123 , 15315821
TBP	TAF1B	NO	in vitro	7801123
TBP	PSMC2	NO	in vivo	11118327
TBP	TAF10	NO	in vitro	7923369
TBP	WDR62	NO	yeast 2-hybrid	16169070
TBP	SUB1	NO	in vitro	9482861
TBP	HMGB1	NO	in vitro	9880542
TBP	DRAP1	NO	in vitro;in vivo	11461703
TBP	TAF12	NO	in vitro	7729427
TBP	EDF1	NO	in vivo	10816571
TBP	SPI1	NO	in vitro	8434021
TBP	PIAS3	NO	yeast 2-hybrid	16522640
TBP	NACA	NO	in vitro;in vivo	8835540
TBP	SNAPC2	NO	in vitro	8633057
TBP	HAP1	NO	yeast 2-hybrid	16713569
TBP	CREG1	NO	in vitro	9710587
TBP	ABT1	NO	in vitro;in vivo	10648625
TBP	BCL3	NO	in vitro	9812988
TBP	NCOA3	NO	in vitro	9267036
TBP	TAF11	NO	in vitro;in vivo	7729427
TBP	BRF2	NO	in vitro;in vivo	11564744
TBP	UBTF	NO	in vivo	8552083
TBP	RB1	NO	in vitro	11094070
TBP	SNAPC4	NO	in vitro	12621023
TBP	PIAS1	NO	in vivo;yeast 2-hybrid	16522640
TBP	IKZF1	NO	in vitro	11959865
TBP	FATE1	NO	yeast 2-hybrid	16713569
TBP	PAX6	NO	in vitro;in vivo	10359315
TBP	TAF1L	NO	yeast 2-hybrid	12217962
TBP	TAF5	NO	in vitro;in vivo	9045704
TBP	GTF2B	NO	in vitro;in vivo	14963322 , 8006019

Related other genetic factors

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variants (count: 1)

Variant Name	Variant Type	Location in Gene	No. of Studies (Positive/Negative/Trend)
TBP_CAG/CAA repeats	microsatellite		1 (0/1/0)

Gene related regions (count: 2)

Region Name	Position	No. of Studies (Positive/Negative/Trend)
Chr 6	chr6:0-170805979	3 (0/3/0)
6q27	chr6:164100000-170805979	1 (0/0/1)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)

Gene relationship with SZ

Overlap with SZ from cross-disorder studies (count: 0)

Overlap with SZ from candidate gene intersection analysis (count: 3)

Reference	ID in SZGene	Result Category
16054804	400	Positive
8886170	400	Negative
19566714	400	Positive

Gene relationship with MDD

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Region: chr6:170554302..170572870 View in gBrowse