Gene Report

Basic Info
Approved Symbol CAMK2A
Previous Symbol CAMKA
Symbol Alias KIAA0968, CaMKIINalpha
Approved Name calcium/calmodulin-dependent protein kinase II alpha
Previous Name calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
Name Alias CaM-kinase II alpha chain, "calcium/calmodulin-dependent protein kinase II alpha-B subunit", "CaM kinase II alpha subunit", "CaMK-II alpha subunit", "calcium/calmodulin-dependent protein kinase type II alpha chain"
Location 5q32
Position chr5:150219491-150290291, -1
External Links HGNC: 1460
Entrez Gene: 815
Ensembl: ENSG00000070808
UCSC: uc003lrt.2
No. of Studies 2 (Positive: 1; Negative: 1; trend: 0)
Overlap with SZ? NO
Overlap with MDD? YES
Gene related studies (count: 2)
Reference Tested Markers Statistical Values/Author Comments Result Category Comment on Study
Ament, S. A., 2015 Coding P-value=0.22, q-value=0.48, Regulatory P-value=0.0014, q-value=0.0086. The gene has significant rare variant associations to BD. Positive Comment on Study
Yosifova, A.,2009 SNP: rs13360565, rs17712679, rs2288799, rs2304042 No SNP of this gene had significant association with BD in our population. Negative Comment on Study
Gene functional annotation
Gene related GO terms (count: 33)

GO terms by PBA (count: 6)

GO terms by database search (count: 27)

Gene related KEGG pathways (count: 8)

KEGG pathways by PBA (count: 3)

KEGG pathways by database search (count: 5)

Gene related BioCarta pathways (count: 5)

Gene related interactors from protein-protein interactions data in HPRD (count: 23)

Related other genetic factors
Gene related SNPs (count: 15)

Literature-origin SNPs (count: 4)

LD-proxies (count: 11)

Gene related CNVs (count: 0)

Gene related other variants (count: 0)

Gene related regions (count: 4)

Overlap with schizophrenia (SZ) and major depressive disorder (MDD)
Gene relationship with SZ

Gene relationship with MDD

Overlap with MDD from cross-disorder studies (count: 0)

Overlap with MDD from candidate gene intersection analysis (count: 1)

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Region: chr5:150219491..150290291 View in gBrowse
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